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Purine Nucleotides Metabolism and Signaling in Huntington’s Disease: Search for a Target for Novel Therapies

Huntington’s disease (HD) is a multi-system disorder that is caused by expanded CAG repeats within the exon-1 of the huntingtin (HTT) gene that translate to the polyglutamine stretch in the HTT protein. HTT interacts with the proteins involved in gene transcription, endocytosis, and metabolism. HTT...

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Detalles Bibliográficos
Autores principales:	Tomczyk, Marta, Glaser, Talita, Slominska, Ewa M., Ulrich, Henning, Smolenski, Ryszard T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234552/ https://www.ncbi.nlm.nih.gov/pubmed/34207177 http://dx.doi.org/10.3390/ijms22126545

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