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White Matter Survival within and around the Hematoma: Quantification by MRI in Patients with Intracerebral Hemorrhage

White matter (WM) injury and survival after intracerebral hemorrhage (ICH) has received insufficient attention. WM disruption surrounding the hematoma has been documented in animal models with histology, but rarely in human ICH with noninvasive means, like magnetic resonance imaging (MRI). A few hum...

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Autores principales: Novakovic, Nemanja, Linzey, Joseph R., Chenevert, Thomas L., Gemmete, Joseph J., Troost, Jonathan P., Xi, Guohua, Keep, Richard F., Pandey, Aditya S., Chaudhary, Neeraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234588/
https://www.ncbi.nlm.nih.gov/pubmed/34207338
http://dx.doi.org/10.3390/biom11060910
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author Novakovic, Nemanja
Linzey, Joseph R.
Chenevert, Thomas L.
Gemmete, Joseph J.
Troost, Jonathan P.
Xi, Guohua
Keep, Richard F.
Pandey, Aditya S.
Chaudhary, Neeraj
author_facet Novakovic, Nemanja
Linzey, Joseph R.
Chenevert, Thomas L.
Gemmete, Joseph J.
Troost, Jonathan P.
Xi, Guohua
Keep, Richard F.
Pandey, Aditya S.
Chaudhary, Neeraj
author_sort Novakovic, Nemanja
collection PubMed
description White matter (WM) injury and survival after intracerebral hemorrhage (ICH) has received insufficient attention. WM disruption surrounding the hematoma has been documented in animal models with histology, but rarely in human ICH with noninvasive means, like magnetic resonance imaging (MRI). A few human MRI studies have investigated changes in long WM tracts after ICH remote from the hematoma, like the corticospinal tract, but have not attempted to obtain an unbiased quantification of WM changes within and around the hematoma over time. This study attempts such quantification from 3 to 30 days post ictus. Thirteen patients with mild to moderate ICH underwent diffusion tensor imaging (DTI) MRI at 3, 14, and 30 days. Fractional anisotropy (FA) maps were used to calculate the volume of tissue with FA > 0.5, both within the hematoma (lesion) and in the perilesional tissue. At day 3, the percentages of both lesional and perilesional tissue with an FA > 0.5 were significantly less than contralateral, unaffected, anatomically identical tissue. This perilesional contralateral difference persisted at day 14, but there was no significant difference at day 30. The loss of perilesional tissue with FA > 0.5 increased with increasing hematoma size at day 3 and day 14. All patients had some tissue within the lesion with FA > 0.5 at all time points. This did not decrease with duration after ictus, suggesting the persistence of white matter within the hematoma/lesion. These results outline an approach to quantify WM injury, both within and surrounding the hematoma, after mild to moderate ICH using DTI MRI. This may be important for monitoring treatment strategies, such as hematoma evacuation, and assessing efficacy noninvasively.
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spelling pubmed-82345882021-06-27 White Matter Survival within and around the Hematoma: Quantification by MRI in Patients with Intracerebral Hemorrhage Novakovic, Nemanja Linzey, Joseph R. Chenevert, Thomas L. Gemmete, Joseph J. Troost, Jonathan P. Xi, Guohua Keep, Richard F. Pandey, Aditya S. Chaudhary, Neeraj Biomolecules Article White matter (WM) injury and survival after intracerebral hemorrhage (ICH) has received insufficient attention. WM disruption surrounding the hematoma has been documented in animal models with histology, but rarely in human ICH with noninvasive means, like magnetic resonance imaging (MRI). A few human MRI studies have investigated changes in long WM tracts after ICH remote from the hematoma, like the corticospinal tract, but have not attempted to obtain an unbiased quantification of WM changes within and around the hematoma over time. This study attempts such quantification from 3 to 30 days post ictus. Thirteen patients with mild to moderate ICH underwent diffusion tensor imaging (DTI) MRI at 3, 14, and 30 days. Fractional anisotropy (FA) maps were used to calculate the volume of tissue with FA > 0.5, both within the hematoma (lesion) and in the perilesional tissue. At day 3, the percentages of both lesional and perilesional tissue with an FA > 0.5 were significantly less than contralateral, unaffected, anatomically identical tissue. This perilesional contralateral difference persisted at day 14, but there was no significant difference at day 30. The loss of perilesional tissue with FA > 0.5 increased with increasing hematoma size at day 3 and day 14. All patients had some tissue within the lesion with FA > 0.5 at all time points. This did not decrease with duration after ictus, suggesting the persistence of white matter within the hematoma/lesion. These results outline an approach to quantify WM injury, both within and surrounding the hematoma, after mild to moderate ICH using DTI MRI. This may be important for monitoring treatment strategies, such as hematoma evacuation, and assessing efficacy noninvasively. MDPI 2021-06-18 /pmc/articles/PMC8234588/ /pubmed/34207338 http://dx.doi.org/10.3390/biom11060910 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Novakovic, Nemanja
Linzey, Joseph R.
Chenevert, Thomas L.
Gemmete, Joseph J.
Troost, Jonathan P.
Xi, Guohua
Keep, Richard F.
Pandey, Aditya S.
Chaudhary, Neeraj
White Matter Survival within and around the Hematoma: Quantification by MRI in Patients with Intracerebral Hemorrhage
title White Matter Survival within and around the Hematoma: Quantification by MRI in Patients with Intracerebral Hemorrhage
title_full White Matter Survival within and around the Hematoma: Quantification by MRI in Patients with Intracerebral Hemorrhage
title_fullStr White Matter Survival within and around the Hematoma: Quantification by MRI in Patients with Intracerebral Hemorrhage
title_full_unstemmed White Matter Survival within and around the Hematoma: Quantification by MRI in Patients with Intracerebral Hemorrhage
title_short White Matter Survival within and around the Hematoma: Quantification by MRI in Patients with Intracerebral Hemorrhage
title_sort white matter survival within and around the hematoma: quantification by mri in patients with intracerebral hemorrhage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234588/
https://www.ncbi.nlm.nih.gov/pubmed/34207338
http://dx.doi.org/10.3390/biom11060910
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