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A comparison between femoral neck and LS-BMD with LS-TBS in T2DM patients: a case control study

BACKGROUND: Despite having higher bone mineral density (BMD) values, type 2 diabetes mellitus (T2DM) patients are at increased risk of fracture. Trabecular bone score (TBS) obtained by evaluating bone microarchitecture might be a more accurate factor for determining bone strength in T2DM patients. I...

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Autores principales: Delbari, Negar, Rajaei, Alireza, Oroei, Mahbobeh, Ahmadzadeh, Arman, Farsad, Faraneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234652/
https://www.ncbi.nlm.nih.gov/pubmed/34172019
http://dx.doi.org/10.1186/s12891-021-04471-7
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author Delbari, Negar
Rajaei, Alireza
Oroei, Mahbobeh
Ahmadzadeh, Arman
Farsad, Faraneh
author_facet Delbari, Negar
Rajaei, Alireza
Oroei, Mahbobeh
Ahmadzadeh, Arman
Farsad, Faraneh
author_sort Delbari, Negar
collection PubMed
description BACKGROUND: Despite having higher bone mineral density (BMD) values, type 2 diabetes mellitus (T2DM) patients are at increased risk of fracture. Trabecular bone score (TBS) obtained by evaluating bone microarchitecture might be a more accurate factor for determining bone strength in T2DM patients. In this study, we aimed at investigating the mean values of lumbar spine (LS) TBS, LS-BMD, and femoral neck BMD in T2DM patients and controls, as well as the ability of LS-TBS and BMD in distinguishing between T2DM patients and controls. METHODS: This case-control study was conducted on 150 patients with T2DM (129 women, 21 men) and 484 controls (424 women, 60 men) in Tehran, Iran. LS-TBS along with femoral neck BMD and LS-BMD was computed using dual-energy X-ray absorptiometry images. Diagnostic accuracy and discriminative capacity of LS-TBS, femoral neck BMD, and LS-BMD between the case and control groups were assessed. RESULTS: T2DM patients showed significantly lower LS-TBS values compared to the control group in the total population and in women. However, in T2DM patients, femoral neck BMD and LS-BMD were found to be significantly higher in the total population and in men, respectively, compared to the control group. Based on area under the curve (AUC) and after adjusting for age and BMI, TBS, LS-BMD, and femoral neck BMD were shown to have the acceptable ability in distinguishing T2DM patients and controls. CONCLUSION: Besides higher BMD and lower TBS values in T2DM patients compared to controls, a similar acceptable discriminative ability of LS-TBS, LS-BMD, and femoral neck BMD in differentiating between T2DM patients and controls was observed in the total population and in women.
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spelling pubmed-82346522021-06-28 A comparison between femoral neck and LS-BMD with LS-TBS in T2DM patients: a case control study Delbari, Negar Rajaei, Alireza Oroei, Mahbobeh Ahmadzadeh, Arman Farsad, Faraneh BMC Musculoskelet Disord Research Article BACKGROUND: Despite having higher bone mineral density (BMD) values, type 2 diabetes mellitus (T2DM) patients are at increased risk of fracture. Trabecular bone score (TBS) obtained by evaluating bone microarchitecture might be a more accurate factor for determining bone strength in T2DM patients. In this study, we aimed at investigating the mean values of lumbar spine (LS) TBS, LS-BMD, and femoral neck BMD in T2DM patients and controls, as well as the ability of LS-TBS and BMD in distinguishing between T2DM patients and controls. METHODS: This case-control study was conducted on 150 patients with T2DM (129 women, 21 men) and 484 controls (424 women, 60 men) in Tehran, Iran. LS-TBS along with femoral neck BMD and LS-BMD was computed using dual-energy X-ray absorptiometry images. Diagnostic accuracy and discriminative capacity of LS-TBS, femoral neck BMD, and LS-BMD between the case and control groups were assessed. RESULTS: T2DM patients showed significantly lower LS-TBS values compared to the control group in the total population and in women. However, in T2DM patients, femoral neck BMD and LS-BMD were found to be significantly higher in the total population and in men, respectively, compared to the control group. Based on area under the curve (AUC) and after adjusting for age and BMI, TBS, LS-BMD, and femoral neck BMD were shown to have the acceptable ability in distinguishing T2DM patients and controls. CONCLUSION: Besides higher BMD and lower TBS values in T2DM patients compared to controls, a similar acceptable discriminative ability of LS-TBS, LS-BMD, and femoral neck BMD in differentiating between T2DM patients and controls was observed in the total population and in women. BioMed Central 2021-06-25 /pmc/articles/PMC8234652/ /pubmed/34172019 http://dx.doi.org/10.1186/s12891-021-04471-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Delbari, Negar
Rajaei, Alireza
Oroei, Mahbobeh
Ahmadzadeh, Arman
Farsad, Faraneh
A comparison between femoral neck and LS-BMD with LS-TBS in T2DM patients: a case control study
title A comparison between femoral neck and LS-BMD with LS-TBS in T2DM patients: a case control study
title_full A comparison between femoral neck and LS-BMD with LS-TBS in T2DM patients: a case control study
title_fullStr A comparison between femoral neck and LS-BMD with LS-TBS in T2DM patients: a case control study
title_full_unstemmed A comparison between femoral neck and LS-BMD with LS-TBS in T2DM patients: a case control study
title_short A comparison between femoral neck and LS-BMD with LS-TBS in T2DM patients: a case control study
title_sort comparison between femoral neck and ls-bmd with ls-tbs in t2dm patients: a case control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234652/
https://www.ncbi.nlm.nih.gov/pubmed/34172019
http://dx.doi.org/10.1186/s12891-021-04471-7
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