Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging

Pyridazino-1,3a,6a-triazapentalenes (PyTAP) are compact fused 6/5/5 tricyclic scaffolds which exhibit promising fluorescent properties. Chemically stable, they can be post-functionalized using standard Pd-catalyzed cross-coupling chemistry. Several original PyTAP bearing additional unsaturated subst...

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Autores principales: Sirbu, Doina, Chopin, Nicolas, Martinić, Ivana, Ndiaye, Moussa, Eliseeva, Svetlana V., Hiebel, Marie-Aude, Petoud, Stéphane, Suzenet, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234658/
https://www.ncbi.nlm.nih.gov/pubmed/34205833
http://dx.doi.org/10.3390/ijms22126645
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author Sirbu, Doina
Chopin, Nicolas
Martinić, Ivana
Ndiaye, Moussa
Eliseeva, Svetlana V.
Hiebel, Marie-Aude
Petoud, Stéphane
Suzenet, Franck
author_facet Sirbu, Doina
Chopin, Nicolas
Martinić, Ivana
Ndiaye, Moussa
Eliseeva, Svetlana V.
Hiebel, Marie-Aude
Petoud, Stéphane
Suzenet, Franck
author_sort Sirbu, Doina
collection PubMed
description Pyridazino-1,3a,6a-triazapentalenes (PyTAP) are compact fused 6/5/5 tricyclic scaffolds which exhibit promising fluorescent properties. Chemically stable, they can be post-functionalized using standard Pd-catalyzed cross-coupling chemistry. Several original PyTAP bearing additional unsaturated substituents in positions 2 and 8 were synthetized and their spectroscopic properties analyzed. They have been successfully tested as fluorescent probes for cellular imaging.
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spelling pubmed-82346582021-06-27 Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging Sirbu, Doina Chopin, Nicolas Martinić, Ivana Ndiaye, Moussa Eliseeva, Svetlana V. Hiebel, Marie-Aude Petoud, Stéphane Suzenet, Franck Int J Mol Sci Article Pyridazino-1,3a,6a-triazapentalenes (PyTAP) are compact fused 6/5/5 tricyclic scaffolds which exhibit promising fluorescent properties. Chemically stable, they can be post-functionalized using standard Pd-catalyzed cross-coupling chemistry. Several original PyTAP bearing additional unsaturated substituents in positions 2 and 8 were synthetized and their spectroscopic properties analyzed. They have been successfully tested as fluorescent probes for cellular imaging. MDPI 2021-06-21 /pmc/articles/PMC8234658/ /pubmed/34205833 http://dx.doi.org/10.3390/ijms22126645 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sirbu, Doina
Chopin, Nicolas
Martinić, Ivana
Ndiaye, Moussa
Eliseeva, Svetlana V.
Hiebel, Marie-Aude
Petoud, Stéphane
Suzenet, Franck
Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging
title Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging
title_full Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging
title_fullStr Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging
title_full_unstemmed Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging
title_short Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging
title_sort pyridazino-1,3a,6a-triazapentalenes as versatile fluorescent probes: impact of their post-functionalization and application for cellular imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234658/
https://www.ncbi.nlm.nih.gov/pubmed/34205833
http://dx.doi.org/10.3390/ijms22126645
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