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Inhibition of Ceramide Synthesis Reduces α-Synuclein Proteinopathy in a Cellular Model of Parkinson’s Disease
Parkinson’s disease (PD) is a proteinopathy associated with the aggregation of α-synuclein and the formation of lipid–protein cellular inclusions, named Lewy bodies (LBs). LB formation results in impaired neurotransmitter release and uptake, which involve membrane traffic and require lipid synthesis...
Autores principales: | Mingione, Alessandra, Pivari, Francesca, Plotegher, Nicoletta, Dei Cas, Michele, Zulueta, Aida, Bocci, Tommaso, Trinchera, Marco, Albi, Elisabetta, Maglione, Vittorio, Caretti, Anna, Bubacco, Luigi, Paroni, Rita, Bottai, Daniele, Ghidoni, Riccardo, Signorelli, Paola |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234676/ https://www.ncbi.nlm.nih.gov/pubmed/34208778 http://dx.doi.org/10.3390/ijms22126469 |
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