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Structural Insights into the Interactions of Digoxin and Na(+)/K(+)-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation
Digoxin is a cardiac glycoside long used to treat congestive heart failure and found recently to show antitumor potential. The hydroxy groups connected at the C-12, C-14, and C-3′a positions; the C-17 unsaturated lactone unit; the conformation of the steroid core; and the C-3 saccharide moiety have...
Autores principales: | Ren, Yulin, Wu, Sijin, Burdette, Joanna E., Cheng, Xiaolin, Kinghorn, A. Douglas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234910/ https://www.ncbi.nlm.nih.gov/pubmed/34208576 http://dx.doi.org/10.3390/molecules26123672 |
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