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Functionalized Particles Designed for Targeted Delivery

Pure bioactive compounds alone can only be exceptionally administered in medical treatment. Usually, drugs are produced as various forms of active compounds and auxiliary substances, combinations assuring the desired healing functions. One of the important drug forms is represented by a combination...

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Detalles Bibliográficos
Autores principales: Basinska, Teresa, Gadzinowski, Mariusz, Mickiewicz, Damian, Slomkowski, Stanislaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234925/
https://www.ncbi.nlm.nih.gov/pubmed/34205672
http://dx.doi.org/10.3390/polym13122022
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author Basinska, Teresa
Gadzinowski, Mariusz
Mickiewicz, Damian
Slomkowski, Stanislaw
author_facet Basinska, Teresa
Gadzinowski, Mariusz
Mickiewicz, Damian
Slomkowski, Stanislaw
author_sort Basinska, Teresa
collection PubMed
description Pure bioactive compounds alone can only be exceptionally administered in medical treatment. Usually, drugs are produced as various forms of active compounds and auxiliary substances, combinations assuring the desired healing functions. One of the important drug forms is represented by a combination of active substances and particle-shaped polymer in the nano- or micrometer size range. The review describes recent progress in this field balanced with basic information. After a brief introduction, the paper presents a concise overview of polymers used as components of nano- and microparticle drug carriers. Thereafter, progress in direct synthesis of polymer particles with functional groups is discussed. A section is devoted to formation of particles by self-assembly of homo- and copolymer-bearing functional groups. Special attention is focused on modification of the primary functional groups introduced during particle preparation, including introduction of ligands promoting anchorage of particles onto the chosen living cell types by interactions with specific receptors present in cell membranes. Particular attention is focused on progress in methods suitable for preparation of particles loaded with bioactive substances. The review ends with a brief discussion of the still not answered questions and unsolved problems.
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spelling pubmed-82349252021-06-27 Functionalized Particles Designed for Targeted Delivery Basinska, Teresa Gadzinowski, Mariusz Mickiewicz, Damian Slomkowski, Stanislaw Polymers (Basel) Review Pure bioactive compounds alone can only be exceptionally administered in medical treatment. Usually, drugs are produced as various forms of active compounds and auxiliary substances, combinations assuring the desired healing functions. One of the important drug forms is represented by a combination of active substances and particle-shaped polymer in the nano- or micrometer size range. The review describes recent progress in this field balanced with basic information. After a brief introduction, the paper presents a concise overview of polymers used as components of nano- and microparticle drug carriers. Thereafter, progress in direct synthesis of polymer particles with functional groups is discussed. A section is devoted to formation of particles by self-assembly of homo- and copolymer-bearing functional groups. Special attention is focused on modification of the primary functional groups introduced during particle preparation, including introduction of ligands promoting anchorage of particles onto the chosen living cell types by interactions with specific receptors present in cell membranes. Particular attention is focused on progress in methods suitable for preparation of particles loaded with bioactive substances. The review ends with a brief discussion of the still not answered questions and unsolved problems. MDPI 2021-06-21 /pmc/articles/PMC8234925/ /pubmed/34205672 http://dx.doi.org/10.3390/polym13122022 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Basinska, Teresa
Gadzinowski, Mariusz
Mickiewicz, Damian
Slomkowski, Stanislaw
Functionalized Particles Designed for Targeted Delivery
title Functionalized Particles Designed for Targeted Delivery
title_full Functionalized Particles Designed for Targeted Delivery
title_fullStr Functionalized Particles Designed for Targeted Delivery
title_full_unstemmed Functionalized Particles Designed for Targeted Delivery
title_short Functionalized Particles Designed for Targeted Delivery
title_sort functionalized particles designed for targeted delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234925/
https://www.ncbi.nlm.nih.gov/pubmed/34205672
http://dx.doi.org/10.3390/polym13122022
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