The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues

SIMPLE SUMMARY: Research in large animal models has been hampered by the complexity to introduce new gene alterations, but this has been simplified by the discovery of the CRISPR/Cas system. Here, we have cloned a Cas9 minipig to generate a porcine model for pre-clinical research. Six viable piglets...

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Detalles Bibliográficos
Autores principales: Berthelsen, Martin Fogtmann, Riedel, Maria, Cai, Huiqiang, Skaarup, Søren H., Alstrup, Aage K. O., Dagnæs-Hansen, Frederik, Luo, Yonglun, Jensen, Uffe B., Hager, Henrik, Liu, Ying, Callesen, Henrik, Vendelbo, Mikkel H., Jakobsen, Jannik E., Thomsen, Martin Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234985/
https://www.ncbi.nlm.nih.gov/pubmed/34208747
http://dx.doi.org/10.3390/cancers13123024

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