Cargando…

Global Alternative Splicing Defects in Human Breast Cancer Cells

SIMPLE SUMMARY: Aberrant alternative splicing (AS) regulation plays a pivotal role in breast cancer development, progression, and resistance to therapeutical interventions. Indeed, cancer cells can adapt their own transcriptome by changing different AS programs, thus generating cancer-specific AS is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oh, Jagyeong, Pradella, Davide, Kim, Yoonseong, Shao, Changwei, Li, Hairi, Choi, Namjeong, Ha, Jiyeon, Di Matteo, Anna, Fu, Xiang-Dong, Zheng, Xuexiu, Ghigna, Claudia, Shen, Haihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235023/ https://www.ncbi.nlm.nih.gov/pubmed/34202984 http://dx.doi.org/10.3390/cancers13123071

Ejemplares similares

Widespread Alternative Splicing Changes in Metastatic Breast Cancer Cells
por: Oh, Jagyeong, et al.
Publicado: (2021)

Opposite Roles of Tra2β and SRSF9 in the v10 Exon Splicing of CD44
por: Oh, Jagyeong, et al.
Publicado: (2020)

Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA
por: Choi, Namjeong, et al.
Publicado: (2021)

U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing
por: Choi, Namjeong, et al.
Publicado: (2020)

SRSF9 Regulates Cassette Exon Splicing of Caspase-2 by Interacting with Its Downstream Exon
por: Ha, Jiyeon, et al.
Publicado: (2021)

hnRNP A1 Regulates Alternative Splicing of Tau Exon 10 by Targeting 3′ Splice Sites
por: Liu, Yongchao, et al.
Publicado: (2020)

SRSF6 Regulates the Alternative Splicing of the Apoptotic Fas Gene by Targeting a Novel RNA Sequence
por: Choi, Namjeong, et al.
Publicado: (2022)

Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping
por: Moon, Heegyum, et al.
Publicado: (2019)

RRM but not the Asp/Glu domain of hnRNP C(1)/C(2) is required for splicing regulation of Ron exon 11 pre-mRNA
por: Moon, Heegyum, et al.
Publicado: (2019)

SRSF2 directly inhibits intron splicing to suppresses cassette exon inclusion
por: Moon, Heegyum, et al.
Publicado: (2017)

EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
por: Pradella, Davide, et al.
Publicado: (2017)

Alternative splicing in endothelial cells: novel therapeutic opportunities in cancer angiogenesis
por: Di Matteo, Anna, et al.
Publicado: (2020)

Gene Expression Profiles Controlled by the Alternative Splicing Factor Nova2 in Endothelial Cells
por: Belloni, Elisa, et al.
Publicado: (2019)

Diversification of the muscle proteome through alternative splicing
por: Nakka, Kiran, et al.
Publicado: (2018)

Alternative Splicing and Tumor Progression
por: Ghigna, Claudia, et al.
Publicado: (2008)

Alternative Splicing: Role in Cancer Development and Progression
por: Sette, Claudio, et al.
Publicado: (2013)

Alternative Splicing: Recent Insights into Mechanisms and Functional Roles
por: Ghigna, Claudia, et al.
Publicado: (2020)

SR proteins regulate V(6) exon splicing of CD44 pre-mRNA
por: Loh, Tiing Jen, et al.
Publicado: (2016)

Identification of Regulatory-RNAs for Alternative Splicing of Ron Proto-Oncogene
por: Moon, Heegyum, et al.
Publicado: (2015)

Alternative Splicing Changes Promoted by NOVA2 Upregulation in Endothelial Cells and Relevance for Gastric Cancer
por: Di Matteo, Anna, et al.
Publicado: (2023)

Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy
por: Bonomi, Serena, et al.
Publicado: (2013)

The alternative splicing factor Nova2 regulates vascular development and lumen formation
por: Giampietro, Costanza, et al.
Publicado: (2015)

A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing
por: Angiolini, Francesca, et al.
Publicado: (2019)

Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer
por: Siegfried, Zahava, et al.
Publicado: (2013)

SAM68: Signal Transduction and RNA Metabolism in Human Cancer
por: Frisone, Paola, et al.
Publicado: (2015)

A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene
por: MOON, HEEGYUM, et al.
Publicado: (2014)

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators
por: Qiu, Jinsong, et al.
Publicado: (2016)

Noncoding RNAs regulate alternative splicing in Cancer
por: Liu, Yunze, et al.
Publicado: (2021)

Polypyrimidine tract binding protein inhibits IgM pre-mRNA splicing by diverting U2 snRNA base-pairing away from the branch point
por: Zheng, Xuexiu, et al.
Publicado: (2014)

A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
por: Pradella, Davide, et al.
Publicado: (2021)

Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB
por: Llorian, Miriam, et al.
Publicado: (2010)

Sam68 regulates EMT through alternative splicing–activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene
por: Valacca, Cristina, et al.
Publicado: (2010)

Identification of neoantigens derived from alternative splicing and RNA modification
por: Park, Jiyeon, et al.
Publicado: (2019)

Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing
por: Darbelli, Lama, et al.
Publicado: (2017)

Global regulation of alternative splicing during myogenic differentiation
por: Bland, Christopher S., et al.
Publicado: (2010)

Global genome splicing analysis reveals an increased number of alternatively spliced genes with aging
por: Rodríguez, Sofía A., et al.
Publicado: (2015)

Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis
por: Yao, Fenyong, et al.
Publicado: (2023)

MicroRNA-Mediated Obstruction of Stem-loop Alternative Splicing (MIMOSAS): a global mechanism for the regulation of alternative splicing
por: Zhai, Rong, et al.
Publicado: (2023)

An Overview of Alternative Splicing Defects Implicated in Myotonic Dystrophy Type I
por: López-Martínez, Andrea, et al.
Publicado: (2020)

Post-Transcriptional Modification by Alternative Splicing and Pathogenic Splicing Variants in Cardiovascular Development and Congenital Heart Defects
por: Mehta, Zubin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_md6t0b873anu18dthor4rm3r91