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Magnetic Resonance Imaging during Proton Therapy Irradiation Allows for the Early Response Assessment of Pediatric Chordoma

Chordoma in pediatric patients is very rare. Proton therapy has become a gold standard in the treatment of these neoplasms, as high dose escalation can be achieved regarding the target while maximizing the sparing of the healthy tissues near the tumor. The aim of the work was to assess the evolution...

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Autores principales: Vennarini, Sabina, Amelio, Dante, Lorentini, Stefano, Colafati, Giovanna Stefania, Cacchione, Antonella, De Vito, Rita, Carai, Andrea, Pettorini, Benedetta, Amichetti, Maurizio, Mastronuzzi, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235054/
https://www.ncbi.nlm.nih.gov/pubmed/34207471
http://dx.doi.org/10.3390/diagnostics11061117
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author Vennarini, Sabina
Amelio, Dante
Lorentini, Stefano
Colafati, Giovanna Stefania
Cacchione, Antonella
De Vito, Rita
Carai, Andrea
Pettorini, Benedetta
Amichetti, Maurizio
Mastronuzzi, Angela
author_facet Vennarini, Sabina
Amelio, Dante
Lorentini, Stefano
Colafati, Giovanna Stefania
Cacchione, Antonella
De Vito, Rita
Carai, Andrea
Pettorini, Benedetta
Amichetti, Maurizio
Mastronuzzi, Angela
author_sort Vennarini, Sabina
collection PubMed
description Chordoma in pediatric patients is very rare. Proton therapy has become a gold standard in the treatment of these neoplasms, as high dose escalation can be achieved regarding the target while maximizing the sparing of the healthy tissues near the tumor. The aim of the work was to assess the evolution of morphological sequences during treatment using T1/T2-weighted magnetic resonance imaging (MRI) for the early response assessment of a classic chordoma of the skull base in a pediatric patient who had undergone surgical excision. Our results demonstrated a significant quantitative reduction in the residual nodule component adhered to the medullary bulb junction, with an almost complete recovery of normal anatomy at the end of the irradiation treatment. This was mainly shown in the T2-weighted MRI. On the other hand, the classic component of the lesion was predominantly present and located around the tooth of the axis. The occipital condyles were morphologically and dimensionally stable for the entire irradiation period. In conclusion, the application of this type of monitoring methodology, which is unusual during the administration of a proton treatment for chordoma, highlighted the unexpected early response of the disease. At the same time, it allowed the continuous assessment of the reliability of the treatment plan.
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spelling pubmed-82350542021-06-27 Magnetic Resonance Imaging during Proton Therapy Irradiation Allows for the Early Response Assessment of Pediatric Chordoma Vennarini, Sabina Amelio, Dante Lorentini, Stefano Colafati, Giovanna Stefania Cacchione, Antonella De Vito, Rita Carai, Andrea Pettorini, Benedetta Amichetti, Maurizio Mastronuzzi, Angela Diagnostics (Basel) Interesting Images Chordoma in pediatric patients is very rare. Proton therapy has become a gold standard in the treatment of these neoplasms, as high dose escalation can be achieved regarding the target while maximizing the sparing of the healthy tissues near the tumor. The aim of the work was to assess the evolution of morphological sequences during treatment using T1/T2-weighted magnetic resonance imaging (MRI) for the early response assessment of a classic chordoma of the skull base in a pediatric patient who had undergone surgical excision. Our results demonstrated a significant quantitative reduction in the residual nodule component adhered to the medullary bulb junction, with an almost complete recovery of normal anatomy at the end of the irradiation treatment. This was mainly shown in the T2-weighted MRI. On the other hand, the classic component of the lesion was predominantly present and located around the tooth of the axis. The occipital condyles were morphologically and dimensionally stable for the entire irradiation period. In conclusion, the application of this type of monitoring methodology, which is unusual during the administration of a proton treatment for chordoma, highlighted the unexpected early response of the disease. At the same time, it allowed the continuous assessment of the reliability of the treatment plan. MDPI 2021-06-18 /pmc/articles/PMC8235054/ /pubmed/34207471 http://dx.doi.org/10.3390/diagnostics11061117 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Vennarini, Sabina
Amelio, Dante
Lorentini, Stefano
Colafati, Giovanna Stefania
Cacchione, Antonella
De Vito, Rita
Carai, Andrea
Pettorini, Benedetta
Amichetti, Maurizio
Mastronuzzi, Angela
Magnetic Resonance Imaging during Proton Therapy Irradiation Allows for the Early Response Assessment of Pediatric Chordoma
title Magnetic Resonance Imaging during Proton Therapy Irradiation Allows for the Early Response Assessment of Pediatric Chordoma
title_full Magnetic Resonance Imaging during Proton Therapy Irradiation Allows for the Early Response Assessment of Pediatric Chordoma
title_fullStr Magnetic Resonance Imaging during Proton Therapy Irradiation Allows for the Early Response Assessment of Pediatric Chordoma
title_full_unstemmed Magnetic Resonance Imaging during Proton Therapy Irradiation Allows for the Early Response Assessment of Pediatric Chordoma
title_short Magnetic Resonance Imaging during Proton Therapy Irradiation Allows for the Early Response Assessment of Pediatric Chordoma
title_sort magnetic resonance imaging during proton therapy irradiation allows for the early response assessment of pediatric chordoma
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235054/
https://www.ncbi.nlm.nih.gov/pubmed/34207471
http://dx.doi.org/10.3390/diagnostics11061117
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