Cargando…
Therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function
Mesenchymal stem cells (MSCs) hold great potential in treating patients with diabetes, but the therapeutic effects are not always achieved. Particularly, the clinical factors regulating MSC therapy in this setting are largely unknown. In this study, 24 patients with type 2 diabetes mellitus (T2DM) t...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235136/ https://www.ncbi.nlm.nih.gov/pubmed/33660433 http://dx.doi.org/10.1002/sctm.20-0303 |
_version_ | 1783714246130925568 |
---|---|
author | Li, Wenwen Jiao, Xuan Song, Jingyun Sui, Bingdong Guo, Zhili Zhao, Yingji Li, Jun Shi, Songtao Huang, Qin |
author_facet | Li, Wenwen Jiao, Xuan Song, Jingyun Sui, Bingdong Guo, Zhili Zhao, Yingji Li, Jun Shi, Songtao Huang, Qin |
author_sort | Li, Wenwen |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) hold great potential in treating patients with diabetes, but the therapeutic effects are not always achieved. Particularly, the clinical factors regulating MSC therapy in this setting are largely unknown. In this study, 24 patients with type 2 diabetes mellitus (T2DM) treated with insulin were selected to receive three intravenous infusions of stem cells from human exfoliated deciduous teeth (SHED) over the course of 6 weeks and were followed up for 12 months. We observed a significant reduction of glycosylated serum albumin level (P < .05) and glycosylated hemoglobin level (P < .05) after SHED transplantation. The total effective rate was 86.36% and 68.18%, respectively, at the end of treatment and follow‐up periods. Three patients ceased insulin injections after SHED transplantation. A steamed bread meal test showed that the serum levels of postprandial C‐peptide at 2 hours were significantly higher than those at the baseline (P < .05). Further analysis showed that patients with a high level of blood cholesterol and a low baseline level of C‐peptide had poor response to SHED transplantation. Some patients experienced a transient fever (11.11%), fatigue (4.17%), or rash (1.39%) after SHED transplantation, which were easily resolved. In summary, SHED infusion is a safe and effective therapy to improve glucose metabolism and islet function in patients with T2DM. Blood lipid levels and baseline islet function may serve as key factors contributing to the therapeutic outcome of MSC transplantation in patients with T2DM. |
format | Online Article Text |
id | pubmed-8235136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82351362021-06-29 Therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function Li, Wenwen Jiao, Xuan Song, Jingyun Sui, Bingdong Guo, Zhili Zhao, Yingji Li, Jun Shi, Songtao Huang, Qin Stem Cells Transl Med Human Clinical Articles Mesenchymal stem cells (MSCs) hold great potential in treating patients with diabetes, but the therapeutic effects are not always achieved. Particularly, the clinical factors regulating MSC therapy in this setting are largely unknown. In this study, 24 patients with type 2 diabetes mellitus (T2DM) treated with insulin were selected to receive three intravenous infusions of stem cells from human exfoliated deciduous teeth (SHED) over the course of 6 weeks and were followed up for 12 months. We observed a significant reduction of glycosylated serum albumin level (P < .05) and glycosylated hemoglobin level (P < .05) after SHED transplantation. The total effective rate was 86.36% and 68.18%, respectively, at the end of treatment and follow‐up periods. Three patients ceased insulin injections after SHED transplantation. A steamed bread meal test showed that the serum levels of postprandial C‐peptide at 2 hours were significantly higher than those at the baseline (P < .05). Further analysis showed that patients with a high level of blood cholesterol and a low baseline level of C‐peptide had poor response to SHED transplantation. Some patients experienced a transient fever (11.11%), fatigue (4.17%), or rash (1.39%) after SHED transplantation, which were easily resolved. In summary, SHED infusion is a safe and effective therapy to improve glucose metabolism and islet function in patients with T2DM. Blood lipid levels and baseline islet function may serve as key factors contributing to the therapeutic outcome of MSC transplantation in patients with T2DM. John Wiley & Sons, Inc. 2021-03-04 /pmc/articles/PMC8235136/ /pubmed/33660433 http://dx.doi.org/10.1002/sctm.20-0303 Text en © 2021 The Authors. stem cells translational medicine published by Wiley Periodicals LLC on behalf of AlphaMed Press. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Human Clinical Articles Li, Wenwen Jiao, Xuan Song, Jingyun Sui, Bingdong Guo, Zhili Zhao, Yingji Li, Jun Shi, Songtao Huang, Qin Therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function |
title | Therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function |
title_full | Therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function |
title_fullStr | Therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function |
title_full_unstemmed | Therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function |
title_short | Therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function |
title_sort | therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function |
topic | Human Clinical Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235136/ https://www.ncbi.nlm.nih.gov/pubmed/33660433 http://dx.doi.org/10.1002/sctm.20-0303 |
work_keys_str_mv | AT liwenwen therapeuticpotentialofstemcellsfromhumanexfoliateddeciduousteethinfusionintopatientswithtype2diabetesdependsonbasallipidlevelsandisletfunction AT jiaoxuan therapeuticpotentialofstemcellsfromhumanexfoliateddeciduousteethinfusionintopatientswithtype2diabetesdependsonbasallipidlevelsandisletfunction AT songjingyun therapeuticpotentialofstemcellsfromhumanexfoliateddeciduousteethinfusionintopatientswithtype2diabetesdependsonbasallipidlevelsandisletfunction AT suibingdong therapeuticpotentialofstemcellsfromhumanexfoliateddeciduousteethinfusionintopatientswithtype2diabetesdependsonbasallipidlevelsandisletfunction AT guozhili therapeuticpotentialofstemcellsfromhumanexfoliateddeciduousteethinfusionintopatientswithtype2diabetesdependsonbasallipidlevelsandisletfunction AT zhaoyingji therapeuticpotentialofstemcellsfromhumanexfoliateddeciduousteethinfusionintopatientswithtype2diabetesdependsonbasallipidlevelsandisletfunction AT lijun therapeuticpotentialofstemcellsfromhumanexfoliateddeciduousteethinfusionintopatientswithtype2diabetesdependsonbasallipidlevelsandisletfunction AT shisongtao therapeuticpotentialofstemcellsfromhumanexfoliateddeciduousteethinfusionintopatientswithtype2diabetesdependsonbasallipidlevelsandisletfunction AT huangqin therapeuticpotentialofstemcellsfromhumanexfoliateddeciduousteethinfusionintopatientswithtype2diabetesdependsonbasallipidlevelsandisletfunction |