Therapeutic Potential of HLA-I Polyreactive mAbs Mimicking the HLA-I Polyreactivity and Immunoregulatory Functions of IVIg

HLA class-I (HLA-I) polyreactive monoclonal antibodies (mAbs) reacting to all HLA-I alleles were developed by immunizing mice with HLA-E monomeric, α-heavy chain (αHC) open conformers (OCs). Two mAbs (TFL-006 and TFL-007) were bound to the αHC’s coated on a solid matrix. The binding was inhibited by...

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Detalles Bibliográficos
Autores principales: Ravindranath, Mepur H., Hilali, Fatiha El, Filippone, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235337/
https://www.ncbi.nlm.nih.gov/pubmed/34205517
http://dx.doi.org/10.3390/vaccines9060680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235337/
https://www.ncbi.nlm.nih.gov/pubmed/34205517
http://dx.doi.org/10.3390/vaccines9060680

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