The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway

SIMPLE SUMMARY: Targeted nanomedicine-based approaches that aim at the simultaneous delivery of synergistic drug combinations to multiple cellular populations are of high relevance for tackling heterogeneity on solid tumors. Considering that cancer stem cells (CSC) may originate from non-stem cancer...

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Detalles Bibliográficos
Autores principales: Cruz, Ana F., Caleiras, Mariana B., Fonseca, Nuno A., Gonçalves, Nélio, Mendes, Vera M., Sampaio, Susana F., Moura, Vera, Melo, Joana B., Almeida, Ramiro D., Manadas, Bruno, Simões, Sérgio, Moreira, João N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235382/
https://www.ncbi.nlm.nih.gov/pubmed/34207464
http://dx.doi.org/10.3390/cancers13123052

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