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A Portable Biodevice to Monitor Salivary Conductivity for the Rapid Assessment of Fluid Status

The evaluation of fluid status can save adults from life-threatening conditions, but the current methods are invasive or time-consuming. Therefore, we developed a portable device for measuring salivary conductivity. This prospective observational study enrolled 20 volunteers with no history of syste...

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Autores principales: Chen, Chun-Hao, Lu, Yen-Pei, Lee, An-Ting, Tung, Chun-Wu, Tsai, Yuan-Hsiung, Tsay, Hsin-Pei, Lin, Chih-Ting, Yang, Jen-Tsung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235451/
https://www.ncbi.nlm.nih.gov/pubmed/34205354
http://dx.doi.org/10.3390/jpm11060577
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author Chen, Chun-Hao
Lu, Yen-Pei
Lee, An-Ting
Tung, Chun-Wu
Tsai, Yuan-Hsiung
Tsay, Hsin-Pei
Lin, Chih-Ting
Yang, Jen-Tsung
author_facet Chen, Chun-Hao
Lu, Yen-Pei
Lee, An-Ting
Tung, Chun-Wu
Tsai, Yuan-Hsiung
Tsay, Hsin-Pei
Lin, Chih-Ting
Yang, Jen-Tsung
author_sort Chen, Chun-Hao
collection PubMed
description The evaluation of fluid status can save adults from life-threatening conditions, but the current methods are invasive or time-consuming. Therefore, we developed a portable device for measuring salivary conductivity. This prospective observational study enrolled 20 volunteers with no history of systemic diseases. Participants were observed for 13 h, including water restriction for 12 h followed by rehydration with 1000 mL water within 1 h. Serum and urine biomarkers for fluid status, thirst scales, and salivary conductivity were collected during dehydration and rehydration. No significant differences in age, body mass index, glycohemoglobin, and estimated glomerular filtration rate were noted between sexes. Salivary conductivity increased after water restriction and decreased after rehydration. Similarly, urine osmolality, urine specific gravity, thirst intensity scales, and body weight followed the same trend and were statistically significant. The angiotensin-converting enzyme and aldosterone levels showed the same trend, without reaching statistical significance. The red blood cell count and hemoglobin concentration also followed the same trend. Analyzing the receiver operating characteristic curves, the area under the curve was 0.707 (95% confidence interval 0.542–0.873, p = 0.025). Using the Youden index, the optimal cutoff determined as 2678.09 μs/cm (sensitivity: 90%, specificity: 55%). This biodevice effectively screened dehydration among healthy adults.
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spelling pubmed-82354512021-06-27 A Portable Biodevice to Monitor Salivary Conductivity for the Rapid Assessment of Fluid Status Chen, Chun-Hao Lu, Yen-Pei Lee, An-Ting Tung, Chun-Wu Tsai, Yuan-Hsiung Tsay, Hsin-Pei Lin, Chih-Ting Yang, Jen-Tsung J Pers Med Article The evaluation of fluid status can save adults from life-threatening conditions, but the current methods are invasive or time-consuming. Therefore, we developed a portable device for measuring salivary conductivity. This prospective observational study enrolled 20 volunteers with no history of systemic diseases. Participants were observed for 13 h, including water restriction for 12 h followed by rehydration with 1000 mL water within 1 h. Serum and urine biomarkers for fluid status, thirst scales, and salivary conductivity were collected during dehydration and rehydration. No significant differences in age, body mass index, glycohemoglobin, and estimated glomerular filtration rate were noted between sexes. Salivary conductivity increased after water restriction and decreased after rehydration. Similarly, urine osmolality, urine specific gravity, thirst intensity scales, and body weight followed the same trend and were statistically significant. The angiotensin-converting enzyme and aldosterone levels showed the same trend, without reaching statistical significance. The red blood cell count and hemoglobin concentration also followed the same trend. Analyzing the receiver operating characteristic curves, the area under the curve was 0.707 (95% confidence interval 0.542–0.873, p = 0.025). Using the Youden index, the optimal cutoff determined as 2678.09 μs/cm (sensitivity: 90%, specificity: 55%). This biodevice effectively screened dehydration among healthy adults. MDPI 2021-06-19 /pmc/articles/PMC8235451/ /pubmed/34205354 http://dx.doi.org/10.3390/jpm11060577 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Chun-Hao
Lu, Yen-Pei
Lee, An-Ting
Tung, Chun-Wu
Tsai, Yuan-Hsiung
Tsay, Hsin-Pei
Lin, Chih-Ting
Yang, Jen-Tsung
A Portable Biodevice to Monitor Salivary Conductivity for the Rapid Assessment of Fluid Status
title A Portable Biodevice to Monitor Salivary Conductivity for the Rapid Assessment of Fluid Status
title_full A Portable Biodevice to Monitor Salivary Conductivity for the Rapid Assessment of Fluid Status
title_fullStr A Portable Biodevice to Monitor Salivary Conductivity for the Rapid Assessment of Fluid Status
title_full_unstemmed A Portable Biodevice to Monitor Salivary Conductivity for the Rapid Assessment of Fluid Status
title_short A Portable Biodevice to Monitor Salivary Conductivity for the Rapid Assessment of Fluid Status
title_sort portable biodevice to monitor salivary conductivity for the rapid assessment of fluid status
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235451/
https://www.ncbi.nlm.nih.gov/pubmed/34205354
http://dx.doi.org/10.3390/jpm11060577
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