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Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology
Cardiovascular diseases (CVDs) are the number one cause of debilitation and mortality worldwide, with a need for cost-effective therapeutics. Autophagy is a highly conserved catabolic recycling pathway triggered by various intra- or extracellular stimuli to play an essential role in development and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235464/ https://www.ncbi.nlm.nih.gov/pubmed/34207151 http://dx.doi.org/10.3390/ijms22126544 |
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author | Bu, Shuhan Singh, Krishna K. |
author_facet | Bu, Shuhan Singh, Krishna K. |
author_sort | Bu, Shuhan |
collection | PubMed |
description | Cardiovascular diseases (CVDs) are the number one cause of debilitation and mortality worldwide, with a need for cost-effective therapeutics. Autophagy is a highly conserved catabolic recycling pathway triggered by various intra- or extracellular stimuli to play an essential role in development and pathologies, including CVDs. Accordingly, there is great interest in identifying mechanisms that govern autophagic regulation. Autophagic regulation is very complex and multifactorial that includes epigenetic pathways, such as histone modifications to regulate autophagy-related gene expression, decapping-associated mRNA degradation, microRNAs, and long non-coding RNAs; pathways are also known to play roles in CVDs. Molecular understanding of epigenetic-based pathways involved in autophagy and CVDs not only will enhance the understanding of CVDs, but may also provide novel therapeutic targets and biomarkers for CVDs. |
format | Online Article Text |
id | pubmed-8235464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82354642021-06-27 Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology Bu, Shuhan Singh, Krishna K. Int J Mol Sci Review Cardiovascular diseases (CVDs) are the number one cause of debilitation and mortality worldwide, with a need for cost-effective therapeutics. Autophagy is a highly conserved catabolic recycling pathway triggered by various intra- or extracellular stimuli to play an essential role in development and pathologies, including CVDs. Accordingly, there is great interest in identifying mechanisms that govern autophagic regulation. Autophagic regulation is very complex and multifactorial that includes epigenetic pathways, such as histone modifications to regulate autophagy-related gene expression, decapping-associated mRNA degradation, microRNAs, and long non-coding RNAs; pathways are also known to play roles in CVDs. Molecular understanding of epigenetic-based pathways involved in autophagy and CVDs not only will enhance the understanding of CVDs, but may also provide novel therapeutic targets and biomarkers for CVDs. MDPI 2021-06-18 /pmc/articles/PMC8235464/ /pubmed/34207151 http://dx.doi.org/10.3390/ijms22126544 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bu, Shuhan Singh, Krishna K. Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology |
title | Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology |
title_full | Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology |
title_fullStr | Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology |
title_full_unstemmed | Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology |
title_short | Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology |
title_sort | epigenetic regulation of autophagy in cardiovascular pathobiology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235464/ https://www.ncbi.nlm.nih.gov/pubmed/34207151 http://dx.doi.org/10.3390/ijms22126544 |
work_keys_str_mv | AT bushuhan epigeneticregulationofautophagyincardiovascularpathobiology AT singhkrishnak epigeneticregulationofautophagyincardiovascularpathobiology |