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Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19

Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is an emergent infectious disease that has caused millions of deaths throughout the world. COVID-19 infection’s main symptoms are fever, cough, fatigue, and neurological manifestations such a...

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Autores principales: Cárdenas-Rodríguez, Noemí, Bandala, Cindy, Vanoye-Carlo, América, Ignacio-Mejía, Iván, Gómez-Manzo, Saúl, Hernández-Cruz, Estefani Yaquelin, Pedraza-Chaverri, José, Carmona-Aparicio, Liliana, Hernández-Ochoa, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235474/
https://www.ncbi.nlm.nih.gov/pubmed/34204362
http://dx.doi.org/10.3390/antiox10060971
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author Cárdenas-Rodríguez, Noemí
Bandala, Cindy
Vanoye-Carlo, América
Ignacio-Mejía, Iván
Gómez-Manzo, Saúl
Hernández-Cruz, Estefani Yaquelin
Pedraza-Chaverri, José
Carmona-Aparicio, Liliana
Hernández-Ochoa, Beatriz
author_facet Cárdenas-Rodríguez, Noemí
Bandala, Cindy
Vanoye-Carlo, América
Ignacio-Mejía, Iván
Gómez-Manzo, Saúl
Hernández-Cruz, Estefani Yaquelin
Pedraza-Chaverri, José
Carmona-Aparicio, Liliana
Hernández-Ochoa, Beatriz
author_sort Cárdenas-Rodríguez, Noemí
collection PubMed
description Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is an emergent infectious disease that has caused millions of deaths throughout the world. COVID-19 infection’s main symptoms are fever, cough, fatigue, and neurological manifestations such as headache, myalgias, anosmia, ageusia, impaired consciousness, seizures, and even neuromuscular junctions’ disorders. In addition, it is known that this disease causes a series of systemic complications such as adverse respiratory distress syndrome, cardiac injury, acute kidney injury, and liver dysfunction. Due to the neurological symptoms associated with COVID-19, damage in the central nervous system has been suggested as well as the neuroinvasive potential of SARS-CoV-2. It is known that CoV infections are associated with an inflammation process related to the imbalance of the antioxidant system; cellular changes caused by oxidative stress contribute to brain tissue damage. Although anti-COVID-19 vaccines are under development, there is no specific treatment for COVID-19 and its clinical manifestations and complications; only supportive treatments with immunomodulators, anti-vascular endothelial growth factors, modulating drugs, statins, or nutritional supplements have been used. In the present work, we analyzed the potential of antioxidants as adjuvants for the treatment of COVID-19 and specifically their possible role in preventing or decreasing the neurological manifestations and neurological complications present in the disease.
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spelling pubmed-82354742021-06-27 Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19 Cárdenas-Rodríguez, Noemí Bandala, Cindy Vanoye-Carlo, América Ignacio-Mejía, Iván Gómez-Manzo, Saúl Hernández-Cruz, Estefani Yaquelin Pedraza-Chaverri, José Carmona-Aparicio, Liliana Hernández-Ochoa, Beatriz Antioxidants (Basel) Review Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is an emergent infectious disease that has caused millions of deaths throughout the world. COVID-19 infection’s main symptoms are fever, cough, fatigue, and neurological manifestations such as headache, myalgias, anosmia, ageusia, impaired consciousness, seizures, and even neuromuscular junctions’ disorders. In addition, it is known that this disease causes a series of systemic complications such as adverse respiratory distress syndrome, cardiac injury, acute kidney injury, and liver dysfunction. Due to the neurological symptoms associated with COVID-19, damage in the central nervous system has been suggested as well as the neuroinvasive potential of SARS-CoV-2. It is known that CoV infections are associated with an inflammation process related to the imbalance of the antioxidant system; cellular changes caused by oxidative stress contribute to brain tissue damage. Although anti-COVID-19 vaccines are under development, there is no specific treatment for COVID-19 and its clinical manifestations and complications; only supportive treatments with immunomodulators, anti-vascular endothelial growth factors, modulating drugs, statins, or nutritional supplements have been used. In the present work, we analyzed the potential of antioxidants as adjuvants for the treatment of COVID-19 and specifically their possible role in preventing or decreasing the neurological manifestations and neurological complications present in the disease. MDPI 2021-06-17 /pmc/articles/PMC8235474/ /pubmed/34204362 http://dx.doi.org/10.3390/antiox10060971 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cárdenas-Rodríguez, Noemí
Bandala, Cindy
Vanoye-Carlo, América
Ignacio-Mejía, Iván
Gómez-Manzo, Saúl
Hernández-Cruz, Estefani Yaquelin
Pedraza-Chaverri, José
Carmona-Aparicio, Liliana
Hernández-Ochoa, Beatriz
Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19
title Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19
title_full Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19
title_fullStr Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19
title_full_unstemmed Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19
title_short Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19
title_sort use of antioxidants for the neuro-therapeutic management of covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235474/
https://www.ncbi.nlm.nih.gov/pubmed/34204362
http://dx.doi.org/10.3390/antiox10060971
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