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Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae

The heterologous gene expression system with Aspergillus oryzae as the host is an effective method to investigate fungal secondary metabolite biosynthetic pathways for reconstruction to produce un-natural molecules due to its high productivity and genetic tractability. In this review, we focus on bi...

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Detalles Bibliográficos
Autores principales: Awakawa, Takayoshi, Abe, Ikuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235479/
https://www.ncbi.nlm.nih.gov/pubmed/34208768
http://dx.doi.org/10.3390/jof7060486
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author Awakawa, Takayoshi
Abe, Ikuro
author_facet Awakawa, Takayoshi
Abe, Ikuro
author_sort Awakawa, Takayoshi
collection PubMed
description The heterologous gene expression system with Aspergillus oryzae as the host is an effective method to investigate fungal secondary metabolite biosynthetic pathways for reconstruction to produce un-natural molecules due to its high productivity and genetic tractability. In this review, we focus on biosynthetic studies of fungal polyketide-derived meroterpenoids, a group of bioactive natural products, by means of the A. oryzae heterologous expression system. The heterologous expression methods and the biosynthetic reactions are described in detail for future prospects to create un-natural molecules via biosynthetic re-design.
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spelling pubmed-82354792021-06-27 Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae Awakawa, Takayoshi Abe, Ikuro J Fungi (Basel) Review The heterologous gene expression system with Aspergillus oryzae as the host is an effective method to investigate fungal secondary metabolite biosynthetic pathways for reconstruction to produce un-natural molecules due to its high productivity and genetic tractability. In this review, we focus on biosynthetic studies of fungal polyketide-derived meroterpenoids, a group of bioactive natural products, by means of the A. oryzae heterologous expression system. The heterologous expression methods and the biosynthetic reactions are described in detail for future prospects to create un-natural molecules via biosynthetic re-design. MDPI 2021-06-16 /pmc/articles/PMC8235479/ /pubmed/34208768 http://dx.doi.org/10.3390/jof7060486 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Awakawa, Takayoshi
Abe, Ikuro
Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae
title Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae
title_full Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae
title_fullStr Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae
title_full_unstemmed Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae
title_short Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae
title_sort reconstitution of polyketide-derived meroterpenoid biosynthetic pathway in aspergillus oryzae
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235479/
https://www.ncbi.nlm.nih.gov/pubmed/34208768
http://dx.doi.org/10.3390/jof7060486
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