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Newborns of Mothers with Venous Disease during Pregnancy Show Increased Levels of Lipid Peroxidation and Markers of Oxidative Stress and Hypoxia in the Umbilical Cord

Chronic venous disease (CVD) encompasses a set of disorders of the venous system that have a high prevalence in Western societies and are associated with significant sociohealth costs. Pregnancy is a period in which different hormonal and haemodynamic changes occur that lead to significant changes i...

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Autores principales: Ortega, Miguel A., Sánchez-Trujillo, Lara, Bravo, Coral, Fraile-Martinez, Oscar, García-Montero, Cielo, Saez, Miguel A., Alvarez-Mon, Miguel A., Sainz, Felipe, Alvarez-Mon, Melchor, Bujan, Julia, De Leon-Luis, Juan A., García-Honduvilla, Natalio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235526/
https://www.ncbi.nlm.nih.gov/pubmed/34207447
http://dx.doi.org/10.3390/antiox10060980
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author Ortega, Miguel A.
Sánchez-Trujillo, Lara
Bravo, Coral
Fraile-Martinez, Oscar
García-Montero, Cielo
Saez, Miguel A.
Alvarez-Mon, Miguel A.
Sainz, Felipe
Alvarez-Mon, Melchor
Bujan, Julia
De Leon-Luis, Juan A.
García-Honduvilla, Natalio
author_facet Ortega, Miguel A.
Sánchez-Trujillo, Lara
Bravo, Coral
Fraile-Martinez, Oscar
García-Montero, Cielo
Saez, Miguel A.
Alvarez-Mon, Miguel A.
Sainz, Felipe
Alvarez-Mon, Melchor
Bujan, Julia
De Leon-Luis, Juan A.
García-Honduvilla, Natalio
author_sort Ortega, Miguel A.
collection PubMed
description Chronic venous disease (CVD) encompasses a set of disorders of the venous system that have a high prevalence in Western societies and are associated with significant sociohealth costs. Pregnancy is a period in which different hormonal and haemodynamic changes occur that lead to significant changes in the cardiovascular system, increasing the risk of developing venous problems, especially during the third trimester of gestation. In turn, CVD involves a series of local and systemic alterations that can have negative repercussions in pregnancy. In this context, the role of oxidative stress in the pathophysiology of this condition has been shown to significantly affect other vascular structures during pregnancy, such as the placenta. However, the effects of oxidative stress on the umbilical cord in women with CVD have not yet been fully elucidated. Thus, the objective of this study was to analyse the gene and protein expression of the enzymes NOX-1, NOX-2 and iNOS, which are involved in the production of reactive oxygen and nitrogen species, respectively. Similarly, the presence of hypoxia-inducible factor 1-alpha (HIF-1α) in the umbilical cord in women with CVD was compared to that of pregnant control women, and the levels of the lipid peroxidation marker malonyldialdehyde (MDA) in cord tissue and blood was also analysed. Our results support a significant increase in the enzymes NOX-1, NOX-2 and iNOS and HIF-1α and MDA in the umbilical cord tissue and blood of women with CVD. For the first time, our work demonstrates an increase in oxidative stress and cellular damage in the umbilical cords of pregnant women who develop this condition, deepening the understanding of the consequences of CVD during pregnancy.
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spelling pubmed-82355262021-06-27 Newborns of Mothers with Venous Disease during Pregnancy Show Increased Levels of Lipid Peroxidation and Markers of Oxidative Stress and Hypoxia in the Umbilical Cord Ortega, Miguel A. Sánchez-Trujillo, Lara Bravo, Coral Fraile-Martinez, Oscar García-Montero, Cielo Saez, Miguel A. Alvarez-Mon, Miguel A. Sainz, Felipe Alvarez-Mon, Melchor Bujan, Julia De Leon-Luis, Juan A. García-Honduvilla, Natalio Antioxidants (Basel) Article Chronic venous disease (CVD) encompasses a set of disorders of the venous system that have a high prevalence in Western societies and are associated with significant sociohealth costs. Pregnancy is a period in which different hormonal and haemodynamic changes occur that lead to significant changes in the cardiovascular system, increasing the risk of developing venous problems, especially during the third trimester of gestation. In turn, CVD involves a series of local and systemic alterations that can have negative repercussions in pregnancy. In this context, the role of oxidative stress in the pathophysiology of this condition has been shown to significantly affect other vascular structures during pregnancy, such as the placenta. However, the effects of oxidative stress on the umbilical cord in women with CVD have not yet been fully elucidated. Thus, the objective of this study was to analyse the gene and protein expression of the enzymes NOX-1, NOX-2 and iNOS, which are involved in the production of reactive oxygen and nitrogen species, respectively. Similarly, the presence of hypoxia-inducible factor 1-alpha (HIF-1α) in the umbilical cord in women with CVD was compared to that of pregnant control women, and the levels of the lipid peroxidation marker malonyldialdehyde (MDA) in cord tissue and blood was also analysed. Our results support a significant increase in the enzymes NOX-1, NOX-2 and iNOS and HIF-1α and MDA in the umbilical cord tissue and blood of women with CVD. For the first time, our work demonstrates an increase in oxidative stress and cellular damage in the umbilical cords of pregnant women who develop this condition, deepening the understanding of the consequences of CVD during pregnancy. MDPI 2021-06-18 /pmc/articles/PMC8235526/ /pubmed/34207447 http://dx.doi.org/10.3390/antiox10060980 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ortega, Miguel A.
Sánchez-Trujillo, Lara
Bravo, Coral
Fraile-Martinez, Oscar
García-Montero, Cielo
Saez, Miguel A.
Alvarez-Mon, Miguel A.
Sainz, Felipe
Alvarez-Mon, Melchor
Bujan, Julia
De Leon-Luis, Juan A.
García-Honduvilla, Natalio
Newborns of Mothers with Venous Disease during Pregnancy Show Increased Levels of Lipid Peroxidation and Markers of Oxidative Stress and Hypoxia in the Umbilical Cord
title Newborns of Mothers with Venous Disease during Pregnancy Show Increased Levels of Lipid Peroxidation and Markers of Oxidative Stress and Hypoxia in the Umbilical Cord
title_full Newborns of Mothers with Venous Disease during Pregnancy Show Increased Levels of Lipid Peroxidation and Markers of Oxidative Stress and Hypoxia in the Umbilical Cord
title_fullStr Newborns of Mothers with Venous Disease during Pregnancy Show Increased Levels of Lipid Peroxidation and Markers of Oxidative Stress and Hypoxia in the Umbilical Cord
title_full_unstemmed Newborns of Mothers with Venous Disease during Pregnancy Show Increased Levels of Lipid Peroxidation and Markers of Oxidative Stress and Hypoxia in the Umbilical Cord
title_short Newborns of Mothers with Venous Disease during Pregnancy Show Increased Levels of Lipid Peroxidation and Markers of Oxidative Stress and Hypoxia in the Umbilical Cord
title_sort newborns of mothers with venous disease during pregnancy show increased levels of lipid peroxidation and markers of oxidative stress and hypoxia in the umbilical cord
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235526/
https://www.ncbi.nlm.nih.gov/pubmed/34207447
http://dx.doi.org/10.3390/antiox10060980
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