Cargando…

Nerolidol Attenuates Oxidative Stress, Inflammation, and Apoptosis by Modulating Nrf2/MAPK Signaling Pathways in Doxorubicin-Induced Acute Cardiotoxicity in Rats

The clinical usage of doxorubicin (DOX), a potent anthracycline antineoplastic drug, is often limited by its cardiotoxic effects. Thus, for improving usage of DOX, the aim of this study was to assess the cardioprotective effects of nerolidol (NERO) in a rat model of DOX-induced acute cardiotoxicity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arunachalam, Seenipandi, Nagoor Meeran, M. F., Azimullah, Sheikh, Sharma, Charu, Goyal, Sameer N., Ojha, Shreesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235529/ https://www.ncbi.nlm.nih.gov/pubmed/34205494 http://dx.doi.org/10.3390/antiox10060984

Ejemplares similares

α-Bisabolol Attenuates NF-κB/MAPK Signaling Activation and ER-Stress-Mediated Apoptosis by Invoking Nrf2-Mediated Antioxidant Defense Systems against Doxorubicin-Induced Testicular Toxicity in Rats
por: Arunachalam, Seenipandi, et al.
Publicado: (2022)

α-Bisabolol Attenuates Doxorubicin Induced Renal Toxicity by Modulating NF-κB/MAPK Signaling and Caspase-Dependent Apoptosis in Rats
por: Arunachalam, Seenipandi, et al.
Publicado: (2022)

α-Bisabolol, a Dietary Sesquiterpene, Attenuates Doxorubicin-Induced Acute Cardiotoxicity in Rats by Inhibiting Cellular Signaling Pathways, Nrf2/Keap-1/HO-1, Akt/mTOR/GSK-3β, NF-κB/p38/MAPK, and NLRP3 Inflammasomes Regulating Oxidative Stress and Inflammatory Cascades
por: Nagoor Meeran, Mohamed Fizur, et al.
Publicado: (2023)

Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats
por: Azimullah, Sheikh, et al.
Publicado: (2023)

Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone
por: Javed, Hayate, et al.
Publicado: (2016)

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19
por: Jha, Niraj Kumar, et al.
Publicado: (2021)

Nootkatone, a Dietary Fragrant Bioactive Compound, Attenuates Dyslipidemia and Intramyocardial Lipid Accumulation and Favorably Alters Lipid Metabolism in a Rat Model of Myocardial Injury: An In Vivo and In Vitro Study
por: Meeran, M.F. Nagoor, et al.
Publicado: (2020)

Can limonene be a possible candidate for evaluation as an agent or adjuvant against infection, immunity, and inflammation in COVID-19?
por: Nagoor Meeran, M.F., et al.
Publicado: (2020)

α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson’s Disease
por: Javed, Hayate, et al.
Publicado: (2020)

Neuroprotective Effects of Thymol, a Dietary Monoterpene Against Dopaminergic Neurodegeneration in Rotenone-Induced Rat Model of Parkinson’s Disease
por: Javed, Hayate, et al.
Publicado: (2019)

Limonene, a Monoterpene, Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Modulating Neuroinflammation, Hippo Signaling and Apoptosis in Rats
por: Eddin, Lujain Bader, et al.
Publicado: (2023)

Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy
por: Azimullah, Sheikh, et al.
Publicado: (2023)

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
por: Nagoor Meeran, Mohamed Fizur, et al.
Publicado: (2017)

Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson’s Disease
por: Jayaraj, Richard L., et al.
Publicado: (2019)

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models
por: Javed, Hayate, et al.
Publicado: (2019)

Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise
por: Nagoor Meeran, Mohamed Fizur, et al.
Publicado: (2018)

Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19
por: Sharma, Charu, et al.
Publicado: (2021)

Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways
por: Jayaraj, Richard L., et al.
Publicado: (2020)

Can Echinacea be a potential candidate to target immunity, inflammation, and infection - The trinity of coronavirus disease 2019
por: Nagoor Meeran, M.F., et al.
Publicado: (2021)

Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity
por: Ojha, Shreesh, et al.
Publicado: (2016)

Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways
por: Jayaraj, Richard L., et al.
Publicado: (2021)

Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System
por: Rathod, Sumit S., et al.
Publicado: (2023)

Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury
por: Subramanya, Sandeep B., et al.
Publicado: (2018)

Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors
por: Pawar, Harshal D., et al.
Publicado: (2022)

Nerolidol Mitigates Colonic Inflammation: An Experimental Study Using both In Vivo and In Vitro Models
por: Raj, Vishnu, et al.
Publicado: (2020)

Therapeutic Potential of β-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications
por: Hashiesh, Hebaallah Mamdouh, et al.
Publicado: (2020)

Thymoquinone Produces Cardioprotective Effect in β-Receptor Stimulated Myocardial Infarcted Rats via Subsiding Oxidative Stress and Inflammation
por: Rathod, Sumit, et al.
Publicado: (2022)

Carvacrol, a Plant Metabolite Targeting Viral Protease (M(pro)) and ACE2 in Host Cells Can Be a Possible Candidate for COVID-19
por: Javed, Hayate, et al.
Publicado: (2021)

Thymoquinone Protects against Myocardial Ischemic Injury by Mitigating Oxidative Stress and Inflammation
por: Ojha, Shreesh, et al.
Publicado: (2015)

Activation of Nrf2 by miR-152 Inhibits Doxorubicin-Induced Cardiotoxicity via Attenuation of Oxidative Stress, Inflammation, and Apoptosis
por: Zhang, Wen-Bin, et al.
Publicado: (2021)

Klotho Improves Cardiac Function by Suppressing Reactive Oxygen Species (ROS) Mediated Apoptosis by Modulating Mapks/Nrf2 Signaling in Doxorubicin-Induced Cardiotoxicity
por: Zhu, Huolan, et al.
Publicado: (2017)

Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
por: Javed, Hayate, et al.
Publicado: (2023)

Nrf2: a dark horse in doxorubicin-induced cardiotoxicity
por: Zhao, Xiaopeng, et al.
Publicado: (2023)

Cannabinoid Type 2 (CB(2)) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease
por: Javed, Hayate, et al.
Publicado: (2016)

miR-200a Attenuated Doxorubicin-Induced Cardiotoxicity through Upregulation of Nrf2 in Mice
por: Hu, Xiaoping, et al.
Publicado: (2019)

Antischistosomal Activity of the Terpene Nerolidol
por: Silva, Marcos P.N., et al.
Publicado: (2014)

An Update on Advancements and Challenges in Inhalational Drug Delivery for Pulmonary Arterial Hypertension
por: Agnihotri, Vinit, et al.
Publicado: (2022)

Telomerase therapy attenuates cardiotoxic effects of doxorubicin
por: Chatterjee, Shambhabi, et al.
Publicado: (2021)

Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin‐induced cardiotoxicity
por: Hu, Can, et al.
Publicado: (2020)

Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction
por: Li, Siying, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4kfnac0r60b6p0a63g1flm5t99