Cargando…

Safety assessment of subtilisin QK in rats

BACKGROUND: Subtilisin QK is a serine protease in the subtilisin family, and is fermented by Bacillus subtilis QK02. The fibrinolytic activity of subtilisin QK was measured by detecting low molecular weight degradation products using a spectrophotometric method developed by Japan Bio Science Laborat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Shuai, Hu, Dingbang, Gao, Ya, Ai, Yang, Luo, Sang, Chen, Song, Wang, Ben, Zhou, Li, Dong, Yanshan, Wang, Yefu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235616/ https://www.ncbi.nlm.nih.gov/pubmed/34172094 http://dx.doi.org/10.1186/s40360-021-00506-w

Ejemplares similares

Subtilisin QK-2: secretory expression in Lactococcus lactis and surface display onto gram-positive enhancer matrix (GEM) particles
por: Mao, Ruifeng, et al.
Publicado: (2016)

Mobius invariant QK spaces
por: Wulan, Hasi, et al.
Publicado: (2017)

In vivo properties of the proangiogenic peptide QK
por: Santulli, Gaetano, et al.
Publicado: (2009)

Wall-crossing, Rogers dilogarithm, and the QK/HK correspondence
por: Alexandrov, Sergei, et al.
Publicado: (2011)

Functional hit 1 (FH1)-based rapid and efficient generation of functional hepatocytes from human mesenchymal stem cells: a novel strategy for hepatic differentiation
por: Luo, Sang, et al.
Publicado: (2021)

Tryptophan Side-Chain Oxidase Enzyme Suppresses Hepatocellular Carcinoma Growth through Degradation of Tryptophan
por: Ai, Yang, et al.
Publicado: (2021)

MiR-126-5p Promotes Tumor Cell Proliferation, Metastasis and Invasion by Targeting TDO2 in Hepatocellular Carcinoma
por: Ai, Yang, et al.
Publicado: (2022)

Changes in the hepatic differentiation potential of human mesenchymal stem cells aged in vitro
por: Luo, Sang, et al.
Publicado: (2021)

SYNE1‐QK1 SNPs, G × G and G × E interactions on the risk of hyperlipidaemia
por: Zheng, Peng‐Fei, et al.
Publicado: (2020)

Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration
por: Li, Runze, et al.
Publicado: (2022)

Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing
por: Darbelli, Lama, et al.
Publicado: (2017)

Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage
por: Takeuchi, Akihide, et al.
Publicado: (2020)

The addition of a polyglutamate domain to the angiogenic QK peptide improves peptide coupling to bone graft materials leading to enhanced endothelial cell activation
por: Pensa, Nicholas W., et al.
Publicado: (2019)

Efficacy and safety of proprotein convertase subtilisin/kexin type 9 monoclonal antibody in adults with familial hypercholesterolemia
por: Li, Bin, et al.
Publicado: (2016)

An assessment of the use of complementary and alternative medicine by Korean people using an adapted version of the standardized international questionnaire (I-CAM-QK): a cross-sectional study of an internet survey
por: Lee, Ju Ah, et al.
Publicado: (2018)

Production of subtilisin proteases in bacteria and yeast
por: Rozanov, A.S., et al.
Publicado: (2021)

Subtilisin-like Pr1 proteases marking the evolution of pathogenicity in a wide-spectrum insect-pathogenic fungus
por: Gao, Ben-Jie, et al.
Publicado: (2020)

Efficiency and Safety of Proprotein Convertase Subtilisin/Kexin 9 Monoclonal Antibody on Hypercholesterolemia: A Meta-Analysis of 20 Randomized Controlled Trials
por: Li, Chuanwei, et al.
Publicado: (2015)

New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina
por: Li, Juan, et al.
Publicado: (2010)

Optimization of subtilisin production from Bacillus subtilis strain ZK3 and biological and molecular characterization of synthesized subtilisin capped nanoparticles
por: Shettar, Shreya S., et al.
Publicado: (2023)

Engineering subtilisin proteases that specifically degrade active RAS
por: Chen, Yingwei, et al.
Publicado: (2021)

Effect of cilostazol on plasma levels of proprotein convertase subtilisin/kexin type 9
por: Chen, I-Chih, et al.
Publicado: (2017)

Development of a novel peptide inhibitor of subtilisin BPN′
por: Ishida, Kohki, et al.
Publicado: (2022)

New robust subtilisins from halotolerant and halophilic Bacillaceae
por: Falkenberg, Fabian, et al.
Publicado: (2023)

Subtilisin of Leishmania amazonensis as Potential Druggable Target: Subcellular Localization, In Vitro Leishmanicidal Activity and Molecular Docking of PF-429242, a Subtilisin Inhibitor
por: Gomes, Pollyanna Stephanie, et al.
Publicado: (2022)

Proprotein convertase subtilisin/kexin type 9 levels and aortic valve calcification: A prospective, cross sectional study
por: Wang, Wen-guang, et al.
Publicado: (2016)

Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats
por: Su, Zhen-li, et al.
Publicado: (2020)

Efficacy and safety profile of a subtilisin protease produced by fermentation in Bacillus licheniformis to be used as a feed additive
por: Cupi, Denisa, et al.
Publicado: (2022)

Safety evaluation of the food enzyme subtilisin from the non‐genetically modified Bacillus paralicheniformis strain LMG S‐30155
por: Lambré, Claude, et al.
Publicado: (2023)

Safety evaluation of the food enzyme subtilisin from the non‐genetically modified Bacillus licheniformis strain NZYM‐CX
por: Lambré, Claude, et al.
Publicado: (2023)

Cyclase-associated protein 1 is a binding partner of proprotein convertase subtilisin/kexin type-9 and is required for the degradation of low-density lipoprotein receptors by proprotein convertase subtilisin/kexin type-9
por: Jang, Hyun-Duk, et al.
Publicado: (2020)

Maturation of subtilisin-like protease NbSLP1 from microsporidia Nosema bombycis
por: Wang, Rong, et al.
Publicado: (2022)

A Practical Preparation of Ribonuclease-S and the Action of Subtilisin on Ribonuclease-B
por: Gordillo, Guido, et al.
Publicado: (1962)

Molecular Determinants of Binding to the Plasmodium Subtilisin-like Protease 1
por: Fulle, Simone, et al.
Publicado: (2013)

Small RNA mediated repression of subtilisin production in Bacillus licheniformis
por: Hertel, Robert, et al.
Publicado: (2017)

Subtilisin-Involved Morphology Engineering for Improved Antibiotic Production in Actinomycetes
por: Wu, Yuanting, et al.
Publicado: (2020)

Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease
por: Wu, Qingyu, et al.
Publicado: (2022)

Immobilization and docking studies of Carlsberg subtilisin for application in poultry industry
por: Rana, Anum Munir, et al.
Publicado: (2023)

Insights into the role of electrostatics in temperature adaptation: a comparative study of psychrophilic, mesophilic, and thermophilic subtilisin-like serine proteases
por: Xia, Yuan-Ling, et al.
Publicado: (2018)

Efficacy and safety of proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, alirocumab and evolocumab, a post-commercialization study
por: Choi, Joshua, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_98lvks3r52lic32gv1sggc5jj6