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Suppressive Antibiotic Treatment in Prosthetic Joint Infections: A Perspective

The treatment of prosthetic joint infections (PJIs) is a complex matter in which surgical, microbiological and pharmacological aspects must be integrated and, above all, placed in the context of each patient to make the best decision. Sometimes it is not possible to offer curative treatment of the i...

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Detalles Bibliográficos
Autores principales: Cobo, Javier, Escudero-Sanchez, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235685/
https://www.ncbi.nlm.nih.gov/pubmed/34205424
http://dx.doi.org/10.3390/antibiotics10060743
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author Cobo, Javier
Escudero-Sanchez, Rosa
author_facet Cobo, Javier
Escudero-Sanchez, Rosa
author_sort Cobo, Javier
collection PubMed
description The treatment of prosthetic joint infections (PJIs) is a complex matter in which surgical, microbiological and pharmacological aspects must be integrated and, above all, placed in the context of each patient to make the best decision. Sometimes it is not possible to offer curative treatment of the infection, and in other cases, the probability that the surgery performed will be successful is considered very low. Therefore, indefinite administration of antibiotics with the intention of “suppressing” the course of the infection becomes useful. For decades, we had little information about suppressive antibiotic treatment (SAT). However, due to the longer life expectancy and increase in orthopaedic surgeries, an increasing number of patients with infected joint prostheses experience complex situations in which SAT should be considered as an alternative. In the last 5 years, several studies attempting to answer the many questions that arise on this issue have been published. The aim of this publication is to review the latest published evidence on SAT.
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spelling pubmed-82356852021-06-27 Suppressive Antibiotic Treatment in Prosthetic Joint Infections: A Perspective Cobo, Javier Escudero-Sanchez, Rosa Antibiotics (Basel) Review The treatment of prosthetic joint infections (PJIs) is a complex matter in which surgical, microbiological and pharmacological aspects must be integrated and, above all, placed in the context of each patient to make the best decision. Sometimes it is not possible to offer curative treatment of the infection, and in other cases, the probability that the surgery performed will be successful is considered very low. Therefore, indefinite administration of antibiotics with the intention of “suppressing” the course of the infection becomes useful. For decades, we had little information about suppressive antibiotic treatment (SAT). However, due to the longer life expectancy and increase in orthopaedic surgeries, an increasing number of patients with infected joint prostheses experience complex situations in which SAT should be considered as an alternative. In the last 5 years, several studies attempting to answer the many questions that arise on this issue have been published. The aim of this publication is to review the latest published evidence on SAT. MDPI 2021-06-19 /pmc/articles/PMC8235685/ /pubmed/34205424 http://dx.doi.org/10.3390/antibiotics10060743 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cobo, Javier
Escudero-Sanchez, Rosa
Suppressive Antibiotic Treatment in Prosthetic Joint Infections: A Perspective
title Suppressive Antibiotic Treatment in Prosthetic Joint Infections: A Perspective
title_full Suppressive Antibiotic Treatment in Prosthetic Joint Infections: A Perspective
title_fullStr Suppressive Antibiotic Treatment in Prosthetic Joint Infections: A Perspective
title_full_unstemmed Suppressive Antibiotic Treatment in Prosthetic Joint Infections: A Perspective
title_short Suppressive Antibiotic Treatment in Prosthetic Joint Infections: A Perspective
title_sort suppressive antibiotic treatment in prosthetic joint infections: a perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235685/
https://www.ncbi.nlm.nih.gov/pubmed/34205424
http://dx.doi.org/10.3390/antibiotics10060743
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