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Total Pancreatectomy with Autologous Islet Cell Transplantation—The Current Indications
Total pancreatectomy is a major complex surgical procedure involving removal of the whole pancreatic parenchyma and duodenum. It leads to lifelong pancreatic exocrine and endocrine insufficiency. The control of surgery-induced diabetes (type 3) requires insulin therapy. Total pancreatectomy with aut...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235694/ https://www.ncbi.nlm.nih.gov/pubmed/34202998 http://dx.doi.org/10.3390/jcm10122723 |
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author | Jabłońska, Beata Mrowiec, Sławomir |
author_facet | Jabłońska, Beata Mrowiec, Sławomir |
author_sort | Jabłońska, Beata |
collection | PubMed |
description | Total pancreatectomy is a major complex surgical procedure involving removal of the whole pancreatic parenchyma and duodenum. It leads to lifelong pancreatic exocrine and endocrine insufficiency. The control of surgery-induced diabetes (type 3) requires insulin therapy. Total pancreatectomy with autologous islet transplantation (TPAIT) is performed in order to prevent postoperative diabetes and its serious complications. It is very important whether it is safe and beneficial for patients in terms of postoperative morbidity and mortality, and long-term results including quality of life. Small duct painful chronic pancreatitis (CP) is a primary indication for TPAIT, but currently the indications for this procedure have been extended. They also include hereditary/genetic pancreatitis (HGP), as well as less frequent indications such as benign/borderline pancreatic tumors (intraductal papillary neoplasms, neuroendocrine neoplasms) and “high-risk pancreatic stump”. The use of TPAIT in malignant pancreatic and peripancreatic neoplasms has been reported in the worldwide literature but currently is not a standard but rather a controversial management in these patients. In this review, history, technique, indications, and contraindications, as well as short-term and long-term results of TPAIT, including pediatric patients, are described. |
format | Online Article Text |
id | pubmed-8235694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82356942021-06-27 Total Pancreatectomy with Autologous Islet Cell Transplantation—The Current Indications Jabłońska, Beata Mrowiec, Sławomir J Clin Med Review Total pancreatectomy is a major complex surgical procedure involving removal of the whole pancreatic parenchyma and duodenum. It leads to lifelong pancreatic exocrine and endocrine insufficiency. The control of surgery-induced diabetes (type 3) requires insulin therapy. Total pancreatectomy with autologous islet transplantation (TPAIT) is performed in order to prevent postoperative diabetes and its serious complications. It is very important whether it is safe and beneficial for patients in terms of postoperative morbidity and mortality, and long-term results including quality of life. Small duct painful chronic pancreatitis (CP) is a primary indication for TPAIT, but currently the indications for this procedure have been extended. They also include hereditary/genetic pancreatitis (HGP), as well as less frequent indications such as benign/borderline pancreatic tumors (intraductal papillary neoplasms, neuroendocrine neoplasms) and “high-risk pancreatic stump”. The use of TPAIT in malignant pancreatic and peripancreatic neoplasms has been reported in the worldwide literature but currently is not a standard but rather a controversial management in these patients. In this review, history, technique, indications, and contraindications, as well as short-term and long-term results of TPAIT, including pediatric patients, are described. MDPI 2021-06-20 /pmc/articles/PMC8235694/ /pubmed/34202998 http://dx.doi.org/10.3390/jcm10122723 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jabłońska, Beata Mrowiec, Sławomir Total Pancreatectomy with Autologous Islet Cell Transplantation—The Current Indications |
title | Total Pancreatectomy with Autologous Islet Cell Transplantation—The Current Indications |
title_full | Total Pancreatectomy with Autologous Islet Cell Transplantation—The Current Indications |
title_fullStr | Total Pancreatectomy with Autologous Islet Cell Transplantation—The Current Indications |
title_full_unstemmed | Total Pancreatectomy with Autologous Islet Cell Transplantation—The Current Indications |
title_short | Total Pancreatectomy with Autologous Islet Cell Transplantation—The Current Indications |
title_sort | total pancreatectomy with autologous islet cell transplantation—the current indications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235694/ https://www.ncbi.nlm.nih.gov/pubmed/34202998 http://dx.doi.org/10.3390/jcm10122723 |
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