Cargando…

The Conspicuous Link between Ear, Brain and Heart–Could Neurotrophin-Treatment of Age-Related Hearing Loss Help Prevent Alzheimer’s Disease and Associated Amyloid Cardiomyopathy?

Alzheimer’s disease (AD), the most common cause of dementia in the elderly, is a neurodegenerative disorder associated with neurovascular dysfunction and cognitive decline. While the deposition of amyloid β peptide (Aβ) and the formation of neurofibrillary tangles (NFTs) are the pathological hallmar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shityakov, Sergey, Hayashi, Kentaro, Störk, Stefan, Scheper, Verena, Lenarz, Thomas, Förster, Carola Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235707/ https://www.ncbi.nlm.nih.gov/pubmed/34204299 http://dx.doi.org/10.3390/biom11060900

Ejemplares similares

Linking Cerebrovascular Dysfunction to Age-Related Hearing Loss and Alzheimer’s Disease—Are Systemic Approaches for Diagnosis and Therapy Required?
por: Förster, Carola Y., et al.
Publicado: (2022)

Local Long-Term Inner Ear Drug Delivery in Normal Hearing Guinea Pig—An Animal Model to Develop Preventive Treatment for Noise-Induced Hearing Loss
por: Malfeld, Kathrin, et al.
Publicado: (2022)

The Protective Effects of Neurotrophins and MicroRNA in Diabetic Retinopathy, Nephropathy and Heart Failure via Regulating Endothelial Function
por: Shityakov, Sergey, et al.
Publicado: (2022)

Prevention of Noise-Induced Hearing Loss In Vivo: Continuous Application of Insulin-like Growth Factor 1 and Its Effect on Inner Ear Synapses, Auditory Function and Perilymph Proteins
por: Malfeld, Kathrin, et al.
Publicado: (2022)

In Situ 3D-Imaging of the Inner Ear Synapses with a Cochlear Implant
por: Malfeld, Kathrin, et al.
Publicado: (2021)

Neural representation in the auditory midbrain of the envelope of vocalizations based on a peripheral ear model
por: Rode, Thilo, et al.
Publicado: (2013)

Uncoiling the Human Cochlea—Physical Scala Tympani Models to Study Pharmacokinetics Inside the Inner Ear
por: Schurzig, Daniel, et al.
Publicado: (2021)

Dexamethasone for Inner Ear Therapy: Biocompatibility and Bio-Efficacy of Different Dexamethasone Formulations In Vitro
por: Gao, Ziwen, et al.
Publicado: (2021)

Conspicuous Chameleons
por: O'Day, Kira E
Publicado: (2008)

All Ears: Potential Help for Noise-Induced Hearing Loss
Publicado: (1999)

3D Printed Cell Culture Chamber for Testing the Effect of Pump-Based Chronic Drug Delivery on Inner Ear Tissue
por: Schwieger, Jana, et al.
Publicado: (2022)

Treatment of Middle Ear Ventilation Disorders: Sheep as Animal Model for Stenting the Human Eustachian Tube – A Cadaver Study
por: Miller, Felicitas, et al.
Publicado: (2014)

Local inner ear application of dexamethasone in cochlear implant models is safe for auditory neurons and increases the neuroprotective effect of chronic electrical stimulation
por: Scheper, Verena, et al.
Publicado: (2017)

In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions
por: Shityakov, Sergey, et al.
Publicado: (2014)

In silico predictive model to determine vector-mediated transport properties for the blood–brain barrier choline transporter
por: Shityakov, Sergey, et al.
Publicado: (2014)

Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins Using Two-Compartment Mathematical Model
por: Shityakov, Sergey, et al.
Publicado: (2013)

Predator feeding choice on conspicuous and non-conspicuous carabid beetles: first results
por: Bonacci, Teresa, et al.
Publicado: (2011)

Deep intracochlear injection of triamcinolone-acetonide with an inner ear catheter in patients with residual hearing
por: Prenzler, Nils K., et al.
Publicado: (2023)

α-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studies
por: Shityakov, Sergey, et al.
Publicado: (2012)

Glucocorticoids and endothelial cell barrier function
por: Salvador, Ellaine, et al.
Publicado: (2013)

Gene expression profiles and protein–protein interaction network analysis in AIDS patients with HIV-associated encephalitis and dementia
por: Shityakov, Sergey, et al.
Publicado: (2015)

Improving Control of Gene Therapy-Based Neurotrophin Delivery for Inner Ear Applications
por: St. Peter, Madeleine, et al.
Publicado: (2022)

In Vitro and In Vivo Evaluation of a Hydrogel Reservoir as a Continuous Drug Delivery System for Inner Ear Treatment
por: Hütten, Mareike, et al.
Publicado: (2014)

Middle Ear Surgery in Only Hearing Ears and Postoperative Hearing Rehabilitation
por: Yoo, Myung Hoon, et al.
Publicado: (2014)

Reliable Measurements of the β-Amyloid Pool in Blood Could Help in the Early Diagnosis of AD
por: Pesini, Pedro, et al.
Publicado: (2012)

Decoration Increases the Conspicuousness of Raptor Nests
por: Canal, David, et al.
Publicado: (2016)

Evaluation and Prediction of the HIV-1 Central Polypurine Tract Influence on Foamy Viral Vectors to Transduce Dividing and Growth-Arrested Cells
por: Shityakov, Sergey, et al.
Publicado: (2014)

Blood–brain barrier transport studies, aggregation, and molecular dynamics simulation of multiwalled carbon nanotube functionalized with fluorescein isothiocyanate
por: Shityakov, Sergey, et al.
Publicado: (2015)

Modeling of shotgun sequencing of DNA plasmids using experimental and theoretical approaches
por: Shityakov, Sergey, et al.
Publicado: (2020)

Neurotrophins and Neurotrophin Receptors in Adult Brain Plasticity
por: Hefti, Franz, et al.
Publicado: (1992)

Neurotrophins and Neurotrophin Receptors in Proliferative Diabetic Retinopathy
por: Abu El-Asrar, Ahmed M., et al.
Publicado: (2013)

Helps to Hear
Publicado: (1882)

ACEMg-mediated hearing preservation in cochlear implant patients receiving different electrode lengths (PROHEARING): study protocol for a randomized controlled trial
por: Scheper, Verena, et al.
Publicado: (2016)

Correlation of Electrically Evoked Compound Action Potential Amplitude Growth Function Slope and Anamnestic Parameters in Cochlear Implant Patients—Identification of Predictors for the Neuronal Health Status
por: Gärtner, Lutz, et al.
Publicado: (2021)

Conspicuous corruption: Evidence at a country level
por: Louridas, Panos, et al.
Publicado: (2021)

Going (in)conspicuous: antecedents and moderators of luxury consumption
por: da Cunha Brandão, Amélia Maria Pinto, et al.
Publicado: (2022)

The evolution of conspicuousness in frogs: When to signal toxicity?
por: Roberts, Sophie May, et al.
Publicado: (2022)

Imperfect Hearing and the Hygiene of the Ear
Publicado: (1881)

Imperfect Hearing and the Hygiene of the Ear
Publicado: (1881)

Development and In-Silico and Ex-Vivo Validation of a Software for a Semi-Automated Segmentation of the Round Window Niche to Design a Patient Specific Implant to Treat Inner Ear Disorders
por: Matin-Mann, Farnaz, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2ms6cmf3bi4qp45kbahet839ha