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Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial

We aimed to evaluate the anatomical and functional outcomes of pars-plana vitrectomy (PPV) with or without autologous platelet concentrate (APC) injection in patients with recurrent macular holes (MHs), large MHs, or MHs with high myopia. This multicenter, prospective, interventional randomized cont...

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Autores principales: Kim, Mirinae, Won, Jae-Yon, Choi, Seung-Yong, Kim, Minhee, Ra, Ho, Jee, Donghyun, Kwon, Jin-Woo, Kang, Kui-Dong, Roh, Young-Jung, Park, Young-Gun, Kang, Seungbum, Shin, Jeong-Ah, Yim, Hyeon-Woo, Park, Young-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235760/
https://www.ncbi.nlm.nih.gov/pubmed/34205522
http://dx.doi.org/10.3390/jcm10122727
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author Kim, Mirinae
Won, Jae-Yon
Choi, Seung-Yong
Kim, Minhee
Ra, Ho
Jee, Donghyun
Kwon, Jin-Woo
Kang, Kui-Dong
Roh, Young-Jung
Park, Young-Gun
Kang, Seungbum
Shin, Jeong-Ah
Yim, Hyeon-Woo
Park, Young-Hoon
author_facet Kim, Mirinae
Won, Jae-Yon
Choi, Seung-Yong
Kim, Minhee
Ra, Ho
Jee, Donghyun
Kwon, Jin-Woo
Kang, Kui-Dong
Roh, Young-Jung
Park, Young-Gun
Kang, Seungbum
Shin, Jeong-Ah
Yim, Hyeon-Woo
Park, Young-Hoon
author_sort Kim, Mirinae
collection PubMed
description We aimed to evaluate the anatomical and functional outcomes of pars-plana vitrectomy (PPV) with or without autologous platelet concentrate (APC) injection in patients with recurrent macular holes (MHs), large MHs, or MHs with high myopia. This multicenter, prospective, interventional randomized controlled trial was conducted from March 2017 to April 2020. Participants were randomly allocated to a PPV group or a PPV+APC group. All participants underwent standard 25-gauge PPV, and eyes in the PPV+APC group underwent PPV with intravitreal APC injection before air-gas exchange. A total of 117 patients were enrolled (PPV group: n = 59, PPV+APC group: n = 58). Hole closure was achieved in 47 participants (79.7%) in the PPV group and 52 participants (89.7%) in the PPV+APC group. There were no between-group differences in the anatomical closure rate or functional outcomes including best-corrected visual acuity, metamorphopsia, pattern-reversal visual evoked potential, or Visual Function Questionnaire-25 score. The use of APC injection does not improve the anatomical and functional outcomes of surgery for large MHs, recurrent MHs, or MHs with high myopia. The adjunctive use of APC can be considered in selected cases because it is not inferior to conventional MH surgery, is relatively simple to perform, and is not affected by the surgeon’s skill.
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spelling pubmed-82357602021-06-27 Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial Kim, Mirinae Won, Jae-Yon Choi, Seung-Yong Kim, Minhee Ra, Ho Jee, Donghyun Kwon, Jin-Woo Kang, Kui-Dong Roh, Young-Jung Park, Young-Gun Kang, Seungbum Shin, Jeong-Ah Yim, Hyeon-Woo Park, Young-Hoon J Clin Med Article We aimed to evaluate the anatomical and functional outcomes of pars-plana vitrectomy (PPV) with or without autologous platelet concentrate (APC) injection in patients with recurrent macular holes (MHs), large MHs, or MHs with high myopia. This multicenter, prospective, interventional randomized controlled trial was conducted from March 2017 to April 2020. Participants were randomly allocated to a PPV group or a PPV+APC group. All participants underwent standard 25-gauge PPV, and eyes in the PPV+APC group underwent PPV with intravitreal APC injection before air-gas exchange. A total of 117 patients were enrolled (PPV group: n = 59, PPV+APC group: n = 58). Hole closure was achieved in 47 participants (79.7%) in the PPV group and 52 participants (89.7%) in the PPV+APC group. There were no between-group differences in the anatomical closure rate or functional outcomes including best-corrected visual acuity, metamorphopsia, pattern-reversal visual evoked potential, or Visual Function Questionnaire-25 score. The use of APC injection does not improve the anatomical and functional outcomes of surgery for large MHs, recurrent MHs, or MHs with high myopia. The adjunctive use of APC can be considered in selected cases because it is not inferior to conventional MH surgery, is relatively simple to perform, and is not affected by the surgeon’s skill. MDPI 2021-06-21 /pmc/articles/PMC8235760/ /pubmed/34205522 http://dx.doi.org/10.3390/jcm10122727 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Mirinae
Won, Jae-Yon
Choi, Seung-Yong
Kim, Minhee
Ra, Ho
Jee, Donghyun
Kwon, Jin-Woo
Kang, Kui-Dong
Roh, Young-Jung
Park, Young-Gun
Kang, Seungbum
Shin, Jeong-Ah
Yim, Hyeon-Woo
Park, Young-Hoon
Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial
title Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial
title_full Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial
title_fullStr Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial
title_full_unstemmed Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial
title_short Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial
title_sort therapeutic efficacy of autologous platelet concentrate injection on macular holes with high myopia, large macular holes, or recurrent macular holes: a multicenter randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235760/
https://www.ncbi.nlm.nih.gov/pubmed/34205522
http://dx.doi.org/10.3390/jcm10122727
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