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Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease

BACKGROUND: Chagas disease is a neglected zoonosis caused by the parasite Trypanosoma cruzi. It affects over six million people, mostly in Latin America. Drugs available to treat T. cruzi infection have associated toxicity and questionable efficacy at the chronic stage. Hence, the discovery of more...

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Autores principales: Martínez-Peinado, Nieves, Cortes-Serra, Nuria, Tallini, Luciana R., Pinazo, Maria-Jesus, Gascon, Joaquim, Bastida, Jaume, Alonso-Padilla, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235838/
https://www.ncbi.nlm.nih.gov/pubmed/34174959
http://dx.doi.org/10.1186/s13071-021-04837-9
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author Martínez-Peinado, Nieves
Cortes-Serra, Nuria
Tallini, Luciana R.
Pinazo, Maria-Jesus
Gascon, Joaquim
Bastida, Jaume
Alonso-Padilla, Julio
author_facet Martínez-Peinado, Nieves
Cortes-Serra, Nuria
Tallini, Luciana R.
Pinazo, Maria-Jesus
Gascon, Joaquim
Bastida, Jaume
Alonso-Padilla, Julio
author_sort Martínez-Peinado, Nieves
collection PubMed
description BACKGROUND: Chagas disease is a neglected zoonosis caused by the parasite Trypanosoma cruzi. It affects over six million people, mostly in Latin America. Drugs available to treat T. cruzi infection have associated toxicity and questionable efficacy at the chronic stage. Hence, the discovery of more effective and safer drugs is an unmet medical need. For this, natural products represent a pool of unique chemical diversity that can serve as excellent templates for the synthesis of active molecules. METHODS: A collection of 79 extracts of Amaryllidaceae plants were screened against T. cruzi. Active extracts against the parasite were progressed through two cell toxicity assays based on Vero and HepG2 cells to determine their selectivity profile and discard those toxic to host cells. Anti-T. cruzi-specific extracts were further qualified by an anti-amastigote stage assay. RESULTS: Two extracts, respectively from Crinum erubescens and Rhodophiala andicola, were identified as highly active and specific against T. cruzi and its mammalian replicative form. CONCLUSIONS: The results retrieved in this study encourage further exploration of the chemical content of these extracts in search of new anti-T. cruzi drug development starting points. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13071-021-04837-9.
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spelling pubmed-82358382021-06-28 Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease Martínez-Peinado, Nieves Cortes-Serra, Nuria Tallini, Luciana R. Pinazo, Maria-Jesus Gascon, Joaquim Bastida, Jaume Alonso-Padilla, Julio Parasit Vectors Research BACKGROUND: Chagas disease is a neglected zoonosis caused by the parasite Trypanosoma cruzi. It affects over six million people, mostly in Latin America. Drugs available to treat T. cruzi infection have associated toxicity and questionable efficacy at the chronic stage. Hence, the discovery of more effective and safer drugs is an unmet medical need. For this, natural products represent a pool of unique chemical diversity that can serve as excellent templates for the synthesis of active molecules. METHODS: A collection of 79 extracts of Amaryllidaceae plants were screened against T. cruzi. Active extracts against the parasite were progressed through two cell toxicity assays based on Vero and HepG2 cells to determine their selectivity profile and discard those toxic to host cells. Anti-T. cruzi-specific extracts were further qualified by an anti-amastigote stage assay. RESULTS: Two extracts, respectively from Crinum erubescens and Rhodophiala andicola, were identified as highly active and specific against T. cruzi and its mammalian replicative form. CONCLUSIONS: The results retrieved in this study encourage further exploration of the chemical content of these extracts in search of new anti-T. cruzi drug development starting points. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13071-021-04837-9. BioMed Central 2021-06-26 /pmc/articles/PMC8235838/ /pubmed/34174959 http://dx.doi.org/10.1186/s13071-021-04837-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Martínez-Peinado, Nieves
Cortes-Serra, Nuria
Tallini, Luciana R.
Pinazo, Maria-Jesus
Gascon, Joaquim
Bastida, Jaume
Alonso-Padilla, Julio
Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease
title Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease
title_full Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease
title_fullStr Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease
title_full_unstemmed Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease
title_short Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease
title_sort amaryllidaceae plants: a potential natural resource for the treatment of chagas disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235838/
https://www.ncbi.nlm.nih.gov/pubmed/34174959
http://dx.doi.org/10.1186/s13071-021-04837-9
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