Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells

BACKGROUND: Vitamin B3 (nicotinamide) plays important roles in metabolism as well as in SIRT and PARP pathways. It is also recently reported as a novel kinase inhibitor with multiple targets. Nicotinamide promotes pancreatic cell differentiation from human embryonic stem cells (hESCs). However, its...

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Detalles Bibliográficos
Autores principales: Zhang, Yumeng, Xu, Jiaqi, Ren, Zhili, Meng, Ya, Liu, Weiwei, Lu, Ligong, Zhou, Zhou, Chen, Guokai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235863/
https://www.ncbi.nlm.nih.gov/pubmed/34172095
http://dx.doi.org/10.1186/s13287-021-02426-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235863/
https://www.ncbi.nlm.nih.gov/pubmed/34172095
http://dx.doi.org/10.1186/s13287-021-02426-2

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