A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim–Sulfamethoxazole

In recent years, there have been an increasing number of infections due to multidrug-resistant organisms in the neonatal intensive care unit. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a challenge in clinical anti-infection treatment. Herein, we report the case of CRKP sepsis in an extreme...

Descripción completa

Detalles Bibliográficos
Autores principales: Weng, Bowen, Zhang, Xiaoyue, Hong, Wenchao, Yan, Chongbing, Gong, Xiaohui, Cai, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235925/
https://www.ncbi.nlm.nih.gov/pubmed/34188498
http://dx.doi.org/10.2147/IDR.S312183
_version_ 1783714430463246336
author Weng, Bowen
Zhang, Xiaoyue
Hong, Wenchao
Yan, Chongbing
Gong, Xiaohui
Cai, Cheng
author_facet Weng, Bowen
Zhang, Xiaoyue
Hong, Wenchao
Yan, Chongbing
Gong, Xiaohui
Cai, Cheng
author_sort Weng, Bowen
collection PubMed
description In recent years, there have been an increasing number of infections due to multidrug-resistant organisms in the neonatal intensive care unit. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a challenge in clinical anti-infection treatment. Herein, we report the case of CRKP sepsis in an extremely low-birth weight infant (ELBWI) who did not respond to meropenem and vancomycin, but was treated successfully after a 10-day antibiotic course with trimethoprim–sulfamethoxazole (TMP-SMZ). Recent research on CRKP-associated sepsis and the application of TMP-SMZ therapy in children and neonates were reviewed to offer a reference for clinical practice.
format Online
Article
Text
id pubmed-8235925
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-82359252021-06-28 A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim–Sulfamethoxazole Weng, Bowen Zhang, Xiaoyue Hong, Wenchao Yan, Chongbing Gong, Xiaohui Cai, Cheng Infect Drug Resist Case Report In recent years, there have been an increasing number of infections due to multidrug-resistant organisms in the neonatal intensive care unit. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a challenge in clinical anti-infection treatment. Herein, we report the case of CRKP sepsis in an extremely low-birth weight infant (ELBWI) who did not respond to meropenem and vancomycin, but was treated successfully after a 10-day antibiotic course with trimethoprim–sulfamethoxazole (TMP-SMZ). Recent research on CRKP-associated sepsis and the application of TMP-SMZ therapy in children and neonates were reviewed to offer a reference for clinical practice. Dove 2021-06-22 /pmc/articles/PMC8235925/ /pubmed/34188498 http://dx.doi.org/10.2147/IDR.S312183 Text en © 2021 Weng et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Weng, Bowen
Zhang, Xiaoyue
Hong, Wenchao
Yan, Chongbing
Gong, Xiaohui
Cai, Cheng
A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim–Sulfamethoxazole
title A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim–Sulfamethoxazole
title_full A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim–Sulfamethoxazole
title_fullStr A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim–Sulfamethoxazole
title_full_unstemmed A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim–Sulfamethoxazole
title_short A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim–Sulfamethoxazole
title_sort case of sepsis due to carbapenem-resistant klebsiella pneumoniae in an extremely low-birth weight infant treated with trimethoprim–sulfamethoxazole
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235925/
https://www.ncbi.nlm.nih.gov/pubmed/34188498
http://dx.doi.org/10.2147/IDR.S312183
work_keys_str_mv AT wengbowen acaseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT zhangxiaoyue acaseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT hongwenchao acaseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT yanchongbing acaseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT gongxiaohui acaseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT caicheng acaseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT wengbowen caseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT zhangxiaoyue caseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT hongwenchao caseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT yanchongbing caseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT gongxiaohui caseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole
AT caicheng caseofsepsisduetocarbapenemresistantklebsiellapneumoniaeinanextremelylowbirthweightinfanttreatedwithtrimethoprimsulfamethoxazole

Ejemplares similares