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Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease
Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235951/ https://www.ncbi.nlm.nih.gov/pubmed/34188515 http://dx.doi.org/10.2147/JIR.S308177 |
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author | Ji, Nan Qi, Zhongwen Wang, Yueyao Yang, Xiaoya Yan, Zhipeng Li, Meng Ge, Qihui Zhang, Junping |
author_facet | Ji, Nan Qi, Zhongwen Wang, Yueyao Yang, Xiaoya Yan, Zhipeng Li, Meng Ge, Qihui Zhang, Junping |
author_sort | Ji, Nan |
collection | PubMed |
description | Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are three different forms of mechanism, which are caspase-1-mediated, caspase-4/5/11-mediated and caspase-3-mediated. A large number of studies have proved that pyroptosis is closely related to cardiovascular disease. This paper reviewed the recent progress in the related research on pyroptosis and myocardial infarction, ischemia-reperfusion, atherosclerosis, diabetic cardiomyopathy, arrhythmia, heart failure hypertension and Kawasaki disease. Therefore, we believe that pyroptosis may be a new therapeutic target in the cardiovascular field. |
format | Online Article Text |
id | pubmed-8235951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-82359512021-06-28 Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease Ji, Nan Qi, Zhongwen Wang, Yueyao Yang, Xiaoya Yan, Zhipeng Li, Meng Ge, Qihui Zhang, Junping J Inflamm Res Review Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are three different forms of mechanism, which are caspase-1-mediated, caspase-4/5/11-mediated and caspase-3-mediated. A large number of studies have proved that pyroptosis is closely related to cardiovascular disease. This paper reviewed the recent progress in the related research on pyroptosis and myocardial infarction, ischemia-reperfusion, atherosclerosis, diabetic cardiomyopathy, arrhythmia, heart failure hypertension and Kawasaki disease. Therefore, we believe that pyroptosis may be a new therapeutic target in the cardiovascular field. Dove 2021-06-22 /pmc/articles/PMC8235951/ /pubmed/34188515 http://dx.doi.org/10.2147/JIR.S308177 Text en © 2021 Ji et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Ji, Nan Qi, Zhongwen Wang, Yueyao Yang, Xiaoya Yan, Zhipeng Li, Meng Ge, Qihui Zhang, Junping Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
title | Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
title_full | Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
title_fullStr | Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
title_full_unstemmed | Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
title_short | Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease |
title_sort | pyroptosis: a new regulating mechanism in cardiovascular disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235951/ https://www.ncbi.nlm.nih.gov/pubmed/34188515 http://dx.doi.org/10.2147/JIR.S308177 |
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