Cargando…

Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion

Treatment resistance in schizophrenia is often encountered in clinical practice, with clozapine usually recommended as the appropriate therapy. However, where clozapine proves ineffective or cannot be tolerated due to side effects, treatment options are limited. In patients within forensic mental he...

Descripción completa

Detalles Bibliográficos
Autores principales: Harrison, Zoe, Haeney, Owen, Brereton, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235956/
https://www.ncbi.nlm.nih.gov/pubmed/34239749
http://dx.doi.org/10.1155/2021/5525398
_version_ 1783714437779161088
author Harrison, Zoe
Haeney, Owen
Brereton, William
author_facet Harrison, Zoe
Haeney, Owen
Brereton, William
author_sort Harrison, Zoe
collection PubMed
description Treatment resistance in schizophrenia is often encountered in clinical practice, with clozapine usually recommended as the appropriate therapy. However, where clozapine proves ineffective or cannot be tolerated due to side effects, treatment options are limited. In patients within forensic mental health services, residual symptomatology often presents a barrier to discharge and can have lasting effects on prospects for rehabilitation as well as risk to self and others. This paper presents a review of the relevant literature and three cases of a novel approach, utilising clozapine in doses usually considered subtherapeutic, in combination with the primary antipsychotic treatment. In all three patients, it improved clinical efficacy as well as tolerability, resulting in improvement that allowed discharge from the forensic hospital.
format Online
Article
Text
id pubmed-8235956
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-82359562021-07-07 Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion Harrison, Zoe Haeney, Owen Brereton, William Case Rep Psychiatry Case Report Treatment resistance in schizophrenia is often encountered in clinical practice, with clozapine usually recommended as the appropriate therapy. However, where clozapine proves ineffective or cannot be tolerated due to side effects, treatment options are limited. In patients within forensic mental health services, residual symptomatology often presents a barrier to discharge and can have lasting effects on prospects for rehabilitation as well as risk to self and others. This paper presents a review of the relevant literature and three cases of a novel approach, utilising clozapine in doses usually considered subtherapeutic, in combination with the primary antipsychotic treatment. In all three patients, it improved clinical efficacy as well as tolerability, resulting in improvement that allowed discharge from the forensic hospital. Hindawi 2021-06-19 /pmc/articles/PMC8235956/ /pubmed/34239749 http://dx.doi.org/10.1155/2021/5525398 Text en Copyright © 2021 Zoe Harrison et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Harrison, Zoe
Haeney, Owen
Brereton, William
Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion
title Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion
title_full Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion
title_fullStr Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion
title_full_unstemmed Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion
title_short Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion
title_sort augmentation of antipsychotic medications with low-dose clozapine in treatment-resistant schizophrenia—case reports and discussion
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235956/
https://www.ncbi.nlm.nih.gov/pubmed/34239749
http://dx.doi.org/10.1155/2021/5525398
work_keys_str_mv AT harrisonzoe augmentationofantipsychoticmedicationswithlowdoseclozapineintreatmentresistantschizophreniacasereportsanddiscussion
AT haeneyowen augmentationofantipsychoticmedicationswithlowdoseclozapineintreatmentresistantschizophreniacasereportsanddiscussion
AT breretonwilliam augmentationofantipsychoticmedicationswithlowdoseclozapineintreatmentresistantschizophreniacasereportsanddiscussion