Cargando…

Jiangzhi Ligan Decoction Inhibits GSDMD-Mediated Canonical/Noncanonical Pyroptosis Pathways and Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease

Increasing evidence suggests that gasdermin D (GSDMD) mediated pyroptosis signaling pathways play a vital role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Jiangzhi Ligan Decoction (JZLGD) has been verified to prevent NAFLD, but its specific mechanism has not been determined. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yin, Kangkang, Zhou, Xiao, Jiang, Wei, Wang, Linlin, Dai, Ziwei, Tang, Biao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235964/ https://www.ncbi.nlm.nih.gov/pubmed/34239622 http://dx.doi.org/10.1155/2021/9963534

Ejemplares similares

Identify Molecular Mechanisms of Jiangzhi Decoction on Nonalcoholic Fatty Liver Disease by Network Pharmacology Analysis and Experimental Validation
por: Wang, Lei, et al.
Publicado: (2020)

Structural and Functional Modulation of Gut Microbiota by Jiangzhi Granules during the Amelioration of Nonalcoholic Fatty Liver Disease
por: Wang, Rui-rui, et al.
Publicado: (2021)

Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia
por: Wang, Kankai, et al.
Publicado: (2020)

Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis
por: Zhuang, Lili, et al.
Publicado: (2022)

Chinese herbal medicine, Jianpi Ligan decoction, improves prognosis of unresectable hepatocellular carcinoma after transarterial chemoembolization: a retrospective study
por: Tang, Cheng Wu, et al.
Publicado: (2016)

Direct Inhibition of GSDMD by PEITC Reduces Hepatocyte Pyroptosis and Alleviates Acute Liver Injury in Mice
por: Wang, Jie, et al.
Publicado: (2022)

GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis
por: Ye, Xiaomiao, et al.
Publicado: (2022)

Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation
por: Wang, Yufang, et al.
Publicado: (2019)

GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy
por: Zuo, Yi, et al.
Publicado: (2021)

Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis
por: Cheng, Ziyu, et al.
Publicado: (2022)

Emodin Alleviates High-Glucose-Induced Pancreatic β-Cell Pyroptosis by Inhibiting NLRP3/GSDMD Signaling
por: Xing, Yiqian, et al.
Publicado: (2022)

Disulfiram alleviates acute lung injury and related intestinal mucosal barrier impairment by targeting GSDMD-dependent pyroptosis
por: Zhao, Jiping, et al.
Publicado: (2022)

Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage
por: Yuan, Bin, et al.
Publicado: (2020)

Inhibition of GSDMD-mediated pyroptosis triggered by Trichinella spiralis intervention contributes to the alleviation of DSS-induced ulcerative colitis in mice
por: Ma, Zhen-Rong, et al.
Publicado: (2023)

GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury
por: Shi, Huairui, et al.
Publicado: (2021)

GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages
por: Jiang, Ping, et al.
Publicado: (2023)

Si-Wu-Tang Alleviates Nonalcoholic Fatty Liver Disease via Blocking TLR4-JNK and Caspase-8-GSDMD Signaling Pathways
por: Zhang, Yaxing, et al.
Publicado: (2020)

Pyroptosis executive protein GSDMD as a biomarker for diagnosis and identification of Alzheimer’s disease
por: Shen, Heping, et al.
Publicado: (2021)

TSPO Deficiency Exacerbates GSDMD-Mediated Macrophage Pyroptosis in Inflammatory Bowel Disease
por: Zhang, Xue, et al.
Publicado: (2022)

IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis
por: Li, Yongxing, et al.
Publicado: (2022)

Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs
por: Liu, Fangfang, et al.
Publicado: (2022)

Features and mechanisms of canonical and noncanonical genomic imprinting
por: Hanna, Courtney W., et al.
Publicado: (2021)

Targeting Noncanonical Pyroptosis With a Small Molecular Inhibitor Alleviates Inflammation in the LPS-Induced Keratitis Mouse Model
por: Zhang, Yun, et al.
Publicado: (2023)

Quantitative determination of multi-class bioactive constituents for quality control of Yiqi Jiangzhi Granules
por: Guo, Shaobo, et al.
Publicado: (2022)

LPS Enhances the Chemosensitivity of Oxaliplatin in HT29 Cells via GSDMD-Mediated Pyroptosis
por: Wu, Li-Sha, et al.
Publicado: (2020)

Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis
por: Lin, Jiahui, et al.
Publicado: (2022)

Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs
por: Hu, Shunlian, et al.
Publicado: (2022)

LDC7559 inhibits microglial activation and GSDMD-dependent pyroptosis after subarachnoid hemorrhage
por: Cai, Wenhua, et al.
Publicado: (2023)

Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
por: Xie, Wei, et al.
Publicado: (2023)

Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion
por: Yang, Lili, et al.
Publicado: (2017)

CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling
por: Xu, Shun, et al.
Publicado: (2020)

Ursolic Acid Alleviates Neuroinflammation after Intracerebral Hemorrhage by Mediating Microglial Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway
por: Lei, Pan, et al.
Publicado: (2023)

β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis
por: Zhang, Di, et al.
Publicado: (2023)

Canonical and Noncanonical Autophagy as Potential Targets for COVID-19
por: Bello-Perez, Melissa, et al.
Publicado: (2020)

Synoviolin alleviates GSDMD‐mediated periodontitis by suppressing its stability
por: Pang, Ying, et al.
Publicado: (2023)

Erratum in: Targeting Noncanonical Pyroptosis With a Small Molecular Inhibitor Alleviates Inflammation in the LPS-Induced Keratitis Mouse Model
Publicado: (2023)

Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway
por: Yang, Jiayao, et al.
Publicado: (2020)

Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL
por: Shi, Chong-Shan, et al.
Publicado: (2019)

Secoisolariciresinol diglucoside induces pyroptosis by activating caspase‐1 to cleave GSDMD in colorectal cancer cells
por: Chen, Tuo, et al.
Publicado: (2022)

Tetracaine hydrochloride induces macrophage pyroptosis through caspase‑1/11‑GSDMD signaling pathways
por: Zhang, Ran, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_envd6bv9hgo13a308o5simjser