A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis

A 66-year-old man with a history of bronchial asthma and sinusitis was admitted with cholecystitis and peripheral neuropathy. The histopathological findings of the gallbladder revealed necrotic vasculitis and granulomatous inflammation with marked eosinophilic infiltration. Kidney biopsy also showed...

Descripción completa

Detalles Bibliográficos
Autores principales: Hattori, Keita, Teramachi, Yuri, Kobayashi, Yoshinori, Ito, Takeshi, Morinaga, Takatoshi, Tamai, Hirohumi, Yamamoto, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235979/
https://www.ncbi.nlm.nih.gov/pubmed/34239754
http://dx.doi.org/10.1155/2021/6678893
_version_ 1783714443241193472
author Hattori, Keita
Teramachi, Yuri
Kobayashi, Yoshinori
Ito, Takeshi
Morinaga, Takatoshi
Tamai, Hirohumi
Yamamoto, Yoshihiro
author_facet Hattori, Keita
Teramachi, Yuri
Kobayashi, Yoshinori
Ito, Takeshi
Morinaga, Takatoshi
Tamai, Hirohumi
Yamamoto, Yoshihiro
author_sort Hattori, Keita
collection PubMed
description A 66-year-old man with a history of bronchial asthma and sinusitis was admitted with cholecystitis and peripheral neuropathy. The histopathological findings of the gallbladder revealed necrotic vasculitis and granulomatous inflammation with marked eosinophilic infiltration. Kidney biopsy also showed marked eosinophilic infiltration in the tubulointerstitial area and eosinophilic tubulitis. He was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) and treated with corticosteroids. However, he showed no response. Therefore, he was administered mepolizumab 300 mg, which resulted in clinical improvement, including normalization of the eosinophil and CRP levels. We herein describe the first case of successful induction therapy of EGPA using mepolizumab.
format Online
Article
Text
id pubmed-8235979
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-82359792021-07-07 A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis Hattori, Keita Teramachi, Yuri Kobayashi, Yoshinori Ito, Takeshi Morinaga, Takatoshi Tamai, Hirohumi Yamamoto, Yoshihiro Case Rep Rheumatol Case Report A 66-year-old man with a history of bronchial asthma and sinusitis was admitted with cholecystitis and peripheral neuropathy. The histopathological findings of the gallbladder revealed necrotic vasculitis and granulomatous inflammation with marked eosinophilic infiltration. Kidney biopsy also showed marked eosinophilic infiltration in the tubulointerstitial area and eosinophilic tubulitis. He was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) and treated with corticosteroids. However, he showed no response. Therefore, he was administered mepolizumab 300 mg, which resulted in clinical improvement, including normalization of the eosinophil and CRP levels. We herein describe the first case of successful induction therapy of EGPA using mepolizumab. Hindawi 2021-06-19 /pmc/articles/PMC8235979/ /pubmed/34239754 http://dx.doi.org/10.1155/2021/6678893 Text en Copyright © 2021 Keita Hattori et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hattori, Keita
Teramachi, Yuri
Kobayashi, Yoshinori
Ito, Takeshi
Morinaga, Takatoshi
Tamai, Hirohumi
Yamamoto, Yoshihiro
A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title_full A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title_fullStr A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title_full_unstemmed A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title_short A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title_sort case of effective mepolizumab induction therapy for severe eosinophilic granulomatosis with polyangiitis diagnosed by eosinophilic cholecystitis and interstitial nephritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235979/
https://www.ncbi.nlm.nih.gov/pubmed/34239754
http://dx.doi.org/10.1155/2021/6678893
work_keys_str_mv AT hattorikeita acaseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT teramachiyuri acaseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT kobayashiyoshinori acaseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT itotakeshi acaseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT morinagatakatoshi acaseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT tamaihirohumi acaseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT yamamotoyoshihiro acaseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT hattorikeita caseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT teramachiyuri caseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT kobayashiyoshinori caseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT itotakeshi caseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT morinagatakatoshi caseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT tamaihirohumi caseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis
AT yamamotoyoshihiro caseofeffectivemepolizumabinductiontherapyforsevereeosinophilicgranulomatosiswithpolyangiitisdiagnosedbyeosinophiliccholecystitisandinterstitialnephritis

Ejemplares similares