“Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis”

BACKGROUND: Vitamin-D is an immune-modulator which might be linked to disease severity by SARS-CoV-2. METHODS: Meta-analysis of RCTs and quasi-experimental studies, evaluating the role of vitamin-D supplementation in COVID patients was done. RESULTS: Total 5 studies (3 RCTs and 2 Quasi-experimental)...

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Autores principales: Rawat, Dimple, Roy, Avishek, Maitra, Souvik, Shankar, Vivek, Khanna, Puneet, Baidya, Dalim Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Diabetes India. Published by Elsevier Ltd. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236412/
https://www.ncbi.nlm.nih.gov/pubmed/34217144
http://dx.doi.org/10.1016/j.dsx.2021.102189
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author Rawat, Dimple
Roy, Avishek
Maitra, Souvik
Shankar, Vivek
Khanna, Puneet
Baidya, Dalim Kumar
author_facet Rawat, Dimple
Roy, Avishek
Maitra, Souvik
Shankar, Vivek
Khanna, Puneet
Baidya, Dalim Kumar
author_sort Rawat, Dimple
collection PubMed
description BACKGROUND: Vitamin-D is an immune-modulator which might be linked to disease severity by SARS-CoV-2. METHODS: Meta-analysis of RCTs and quasi-experimental studies, evaluating the role of vitamin-D supplementation in COVID patients was done. RESULTS: Total 5 studies (3 RCTs and 2 Quasi-experimental) including n = 467 patients were included. Vitamin D didn't reduce mortality (RR 0.55, 95%CI 0.22 to 1.39, p = 0.21), ICU admission rates (RR 0.20, 95% CI 0.01–4.26, p = 0.3) and need for invasive ventilation (RR 0.24, 95% CI 0.01–7.89, p = 0.42). CONCLUSION: No significant difference with vitamin-D supplementation on major health related outcomes in COVID-19. Well-designed RCTs are required addressing this topic.
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spelling pubmed-82364122021-06-28 “Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis” Rawat, Dimple Roy, Avishek Maitra, Souvik Shankar, Vivek Khanna, Puneet Baidya, Dalim Kumar Diabetes Metab Syndr Review BACKGROUND: Vitamin-D is an immune-modulator which might be linked to disease severity by SARS-CoV-2. METHODS: Meta-analysis of RCTs and quasi-experimental studies, evaluating the role of vitamin-D supplementation in COVID patients was done. RESULTS: Total 5 studies (3 RCTs and 2 Quasi-experimental) including n = 467 patients were included. Vitamin D didn't reduce mortality (RR 0.55, 95%CI 0.22 to 1.39, p = 0.21), ICU admission rates (RR 0.20, 95% CI 0.01–4.26, p = 0.3) and need for invasive ventilation (RR 0.24, 95% CI 0.01–7.89, p = 0.42). CONCLUSION: No significant difference with vitamin-D supplementation on major health related outcomes in COVID-19. Well-designed RCTs are required addressing this topic. Diabetes India. Published by Elsevier Ltd. 2021 2021-06-28 /pmc/articles/PMC8236412/ /pubmed/34217144 http://dx.doi.org/10.1016/j.dsx.2021.102189 Text en © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Rawat, Dimple
Roy, Avishek
Maitra, Souvik
Shankar, Vivek
Khanna, Puneet
Baidya, Dalim Kumar
“Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis”
title “Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis”
title_full “Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis”
title_fullStr “Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis”
title_full_unstemmed “Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis”
title_short “Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis”
title_sort “vitamin d supplementation and covid-19 treatment: a systematic review and meta-analysis”
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236412/
https://www.ncbi.nlm.nih.gov/pubmed/34217144
http://dx.doi.org/10.1016/j.dsx.2021.102189
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