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Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016
PURPOSE: To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). METHODS: This population-based case–control study included childhood GCT cases in Denmark diagnosed 1...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236473/ https://www.ncbi.nlm.nih.gov/pubmed/33907877 http://dx.doi.org/10.1007/s10552-021-01434-0 |
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author | Hall, Clinton Hansen, Johnni Olsen, Jørn He, Di von Ehrenstein, Ondine S. Ritz, Beate Heck, Julia E. |
author_facet | Hall, Clinton Hansen, Johnni Olsen, Jørn He, Di von Ehrenstein, Ondine S. Ritz, Beate Heck, Julia E. |
author_sort | Hall, Clinton |
collection | PubMed |
description | PURPOSE: To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). METHODS: This population-based case–control study included childhood GCT cases in Denmark diagnosed 1968–2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs). RESULTS: Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23–4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94–14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30–4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77–2.95). CONCLUSION: Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10552-021-01434-0. |
format | Online Article Text |
id | pubmed-8236473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-82364732021-07-09 Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016 Hall, Clinton Hansen, Johnni Olsen, Jørn He, Di von Ehrenstein, Ondine S. Ritz, Beate Heck, Julia E. Cancer Causes Control Original Paper PURPOSE: To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). METHODS: This population-based case–control study included childhood GCT cases in Denmark diagnosed 1968–2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs). RESULTS: Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23–4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94–14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30–4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77–2.95). CONCLUSION: Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10552-021-01434-0. Springer International Publishing 2021-04-28 2021 /pmc/articles/PMC8236473/ /pubmed/33907877 http://dx.doi.org/10.1007/s10552-021-01434-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Hall, Clinton Hansen, Johnni Olsen, Jørn He, Di von Ehrenstein, Ondine S. Ritz, Beate Heck, Julia E. Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016 |
title | Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016 |
title_full | Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016 |
title_fullStr | Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016 |
title_full_unstemmed | Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016 |
title_short | Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016 |
title_sort | parental occupation and childhood germ cell tumors: a case–control study in denmark, 1968–2016 |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236473/ https://www.ncbi.nlm.nih.gov/pubmed/33907877 http://dx.doi.org/10.1007/s10552-021-01434-0 |
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