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Clinical Outcomes Following Single vs. Multiple Vessel Living-Donor Kidney Transplantation: A Retrospective Comparison of 210 Patients

Background: The use of living-donor kidney allografts with multiple vessels continues to rise in order to increase the donor pool. This requires surgeons to pursue vascular reconstructions more often, which has previously been associated with a higher risk of developing early post-transplant complic...

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Autores principales: Garcia, Leonardo E., Parra, Natalia, Gaynor, Jeffrey J., Baker, Lauren, Guerra, Giselle, Ciancio, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236516/
https://www.ncbi.nlm.nih.gov/pubmed/34195224
http://dx.doi.org/10.3389/fsurg.2021.693021
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author Garcia, Leonardo E.
Parra, Natalia
Gaynor, Jeffrey J.
Baker, Lauren
Guerra, Giselle
Ciancio, Gaetano
author_facet Garcia, Leonardo E.
Parra, Natalia
Gaynor, Jeffrey J.
Baker, Lauren
Guerra, Giselle
Ciancio, Gaetano
author_sort Garcia, Leonardo E.
collection PubMed
description Background: The use of living-donor kidney allografts with multiple vessels continues to rise in order to increase the donor pool. This requires surgeons to pursue vascular reconstructions more often, which has previously been associated with a higher risk of developing early post-transplant complications. We therefore wanted to investigate the prognostic role of using living-donor renal allografts with a single artery (SA) vs. multiple arteries (MA) at the time of transplant. Methods: We retrospectively analyzed a cohort of 210 consecutive living-donor kidney transplants performed between January, 2008 and March, 2019, and compared the incidence of developing postoperative complications and other clinical outcomes between SA vs. MA recipients. Results: No differences were observed between SA (N = 161) and MA (N = 49) kidneys in terms of the incidence of developing a postoperative (or surgical) complication, a urologic complication, hospital length of stay, delayed graft function, estimated glomerular filtration rate at 3 or 12 mo post-transplant, and graft survival. Conclusions: The use of live-kidney allografts with MA requiring vascular reconstruction shows excellent clinical outcomes and does not increase the risk of developing postoperative complications or other adverse outcomes when compared with SA renal allografts.
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spelling pubmed-82365162021-06-29 Clinical Outcomes Following Single vs. Multiple Vessel Living-Donor Kidney Transplantation: A Retrospective Comparison of 210 Patients Garcia, Leonardo E. Parra, Natalia Gaynor, Jeffrey J. Baker, Lauren Guerra, Giselle Ciancio, Gaetano Front Surg Surgery Background: The use of living-donor kidney allografts with multiple vessels continues to rise in order to increase the donor pool. This requires surgeons to pursue vascular reconstructions more often, which has previously been associated with a higher risk of developing early post-transplant complications. We therefore wanted to investigate the prognostic role of using living-donor renal allografts with a single artery (SA) vs. multiple arteries (MA) at the time of transplant. Methods: We retrospectively analyzed a cohort of 210 consecutive living-donor kidney transplants performed between January, 2008 and March, 2019, and compared the incidence of developing postoperative complications and other clinical outcomes between SA vs. MA recipients. Results: No differences were observed between SA (N = 161) and MA (N = 49) kidneys in terms of the incidence of developing a postoperative (or surgical) complication, a urologic complication, hospital length of stay, delayed graft function, estimated glomerular filtration rate at 3 or 12 mo post-transplant, and graft survival. Conclusions: The use of live-kidney allografts with MA requiring vascular reconstruction shows excellent clinical outcomes and does not increase the risk of developing postoperative complications or other adverse outcomes when compared with SA renal allografts. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8236516/ /pubmed/34195224 http://dx.doi.org/10.3389/fsurg.2021.693021 Text en Copyright © 2021 Garcia, Parra, Gaynor, Baker, Guerra and Ciancio. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Garcia, Leonardo E.
Parra, Natalia
Gaynor, Jeffrey J.
Baker, Lauren
Guerra, Giselle
Ciancio, Gaetano
Clinical Outcomes Following Single vs. Multiple Vessel Living-Donor Kidney Transplantation: A Retrospective Comparison of 210 Patients
title Clinical Outcomes Following Single vs. Multiple Vessel Living-Donor Kidney Transplantation: A Retrospective Comparison of 210 Patients
title_full Clinical Outcomes Following Single vs. Multiple Vessel Living-Donor Kidney Transplantation: A Retrospective Comparison of 210 Patients
title_fullStr Clinical Outcomes Following Single vs. Multiple Vessel Living-Donor Kidney Transplantation: A Retrospective Comparison of 210 Patients
title_full_unstemmed Clinical Outcomes Following Single vs. Multiple Vessel Living-Donor Kidney Transplantation: A Retrospective Comparison of 210 Patients
title_short Clinical Outcomes Following Single vs. Multiple Vessel Living-Donor Kidney Transplantation: A Retrospective Comparison of 210 Patients
title_sort clinical outcomes following single vs. multiple vessel living-donor kidney transplantation: a retrospective comparison of 210 patients
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236516/
https://www.ncbi.nlm.nih.gov/pubmed/34195224
http://dx.doi.org/10.3389/fsurg.2021.693021
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