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Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors

Oxytocin (OT) is a neuropeptide produced by hypothalamic neurons and is known to modulate social behavior among other functions. Several experiments have shown that OT modulates neuronal activity in many brain areas, including sensory cortices. OT neurons thus project axons to various cortical and s...

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Autores principales: Lefevre, Arthur, Benusiglio, Diego, Tang, Yan, Krabichler, Quirin, Charlet, Alexandre, Grinevich, Valery
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236528/
https://www.ncbi.nlm.nih.gov/pubmed/34194303
http://dx.doi.org/10.3389/fncir.2021.688234
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author Lefevre, Arthur
Benusiglio, Diego
Tang, Yan
Krabichler, Quirin
Charlet, Alexandre
Grinevich, Valery
author_facet Lefevre, Arthur
Benusiglio, Diego
Tang, Yan
Krabichler, Quirin
Charlet, Alexandre
Grinevich, Valery
author_sort Lefevre, Arthur
collection PubMed
description Oxytocin (OT) is a neuropeptide produced by hypothalamic neurons and is known to modulate social behavior among other functions. Several experiments have shown that OT modulates neuronal activity in many brain areas, including sensory cortices. OT neurons thus project axons to various cortical and subcortical structures and activate neuronal subpopulations to increase the signal-to-noise ratio, and in turn, increases the saliency of social stimuli. Less is known about the origin of inputs to OT neurons, but recent studies show that cells projecting to OT neurons are often located in regions where the OT receptor (OTR) is expressed. Thus, we propose the existence of reciprocal connectivity between OT neurons and extrahypothalamic OTR neurons to tune OT neuron activity depending on the behavioral context. Furthermore, the latest studies have shown that OTR-expressing neurons located in social brain regions also project to other social brain regions containing OTR-expressing neurons. We hypothesize that OTR-expressing neurons across the brain constitute a common network coordinated by OT.
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spelling pubmed-82365282021-06-29 Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors Lefevre, Arthur Benusiglio, Diego Tang, Yan Krabichler, Quirin Charlet, Alexandre Grinevich, Valery Front Neural Circuits Neuroscience Oxytocin (OT) is a neuropeptide produced by hypothalamic neurons and is known to modulate social behavior among other functions. Several experiments have shown that OT modulates neuronal activity in many brain areas, including sensory cortices. OT neurons thus project axons to various cortical and subcortical structures and activate neuronal subpopulations to increase the signal-to-noise ratio, and in turn, increases the saliency of social stimuli. Less is known about the origin of inputs to OT neurons, but recent studies show that cells projecting to OT neurons are often located in regions where the OT receptor (OTR) is expressed. Thus, we propose the existence of reciprocal connectivity between OT neurons and extrahypothalamic OTR neurons to tune OT neuron activity depending on the behavioral context. Furthermore, the latest studies have shown that OTR-expressing neurons located in social brain regions also project to other social brain regions containing OTR-expressing neurons. We hypothesize that OTR-expressing neurons across the brain constitute a common network coordinated by OT. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8236528/ /pubmed/34194303 http://dx.doi.org/10.3389/fncir.2021.688234 Text en Copyright © 2021 Lefevre, Benusiglio, Tang, Krabichler, Charlet and Grinevich. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lefevre, Arthur
Benusiglio, Diego
Tang, Yan
Krabichler, Quirin
Charlet, Alexandre
Grinevich, Valery
Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors
title Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors
title_full Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors
title_fullStr Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors
title_full_unstemmed Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors
title_short Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors
title_sort oxytocinergic feedback circuitries: an anatomical basis for neuromodulation of social behaviors
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236528/
https://www.ncbi.nlm.nih.gov/pubmed/34194303
http://dx.doi.org/10.3389/fncir.2021.688234
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