Cargando…
Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation
The formation of synapses is a tightly regulated process that requires the coordinated assembly of the presynaptic and postsynaptic sides. Defects in synaptogenesis during development or in the adult can lead to neurodevelopmental disorders, neurological disorders, and neurodegenerative diseases. In...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236581/ https://www.ncbi.nlm.nih.gov/pubmed/34194299 http://dx.doi.org/10.3389/fnmol.2021.683035 |
_version_ | 1783714568067874816 |
---|---|
author | Teo, Samuel Salinas, Patricia C. |
author_facet | Teo, Samuel Salinas, Patricia C. |
author_sort | Teo, Samuel |
collection | PubMed |
description | The formation of synapses is a tightly regulated process that requires the coordinated assembly of the presynaptic and postsynaptic sides. Defects in synaptogenesis during development or in the adult can lead to neurodevelopmental disorders, neurological disorders, and neurodegenerative diseases. In order to develop therapeutic approaches for these neurological conditions, we must first understand the molecular mechanisms that regulate synapse formation. The Wnt family of secreted glycoproteins are key regulators of synapse formation in different model systems from invertebrates to mammals. In this review, we will discuss the role of Wnt signaling in the formation of excitatory synapses in the mammalian brain by focusing on Wnt7a and Wnt5a, two Wnt ligands that play an in vivo role in this process. We will also discuss how changes in neuronal activity modulate the expression and/or release of Wnts, resulting in changes in the localization of surface levels of Frizzled, key Wnt receptors, at the synapse. Thus, changes in neuronal activity influence the magnitude of Wnt signaling, which in turn contributes to activity-mediated synapse formation. |
format | Online Article Text |
id | pubmed-8236581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82365812021-06-29 Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation Teo, Samuel Salinas, Patricia C. Front Mol Neurosci Molecular Neuroscience The formation of synapses is a tightly regulated process that requires the coordinated assembly of the presynaptic and postsynaptic sides. Defects in synaptogenesis during development or in the adult can lead to neurodevelopmental disorders, neurological disorders, and neurodegenerative diseases. In order to develop therapeutic approaches for these neurological conditions, we must first understand the molecular mechanisms that regulate synapse formation. The Wnt family of secreted glycoproteins are key regulators of synapse formation in different model systems from invertebrates to mammals. In this review, we will discuss the role of Wnt signaling in the formation of excitatory synapses in the mammalian brain by focusing on Wnt7a and Wnt5a, two Wnt ligands that play an in vivo role in this process. We will also discuss how changes in neuronal activity modulate the expression and/or release of Wnts, resulting in changes in the localization of surface levels of Frizzled, key Wnt receptors, at the synapse. Thus, changes in neuronal activity influence the magnitude of Wnt signaling, which in turn contributes to activity-mediated synapse formation. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8236581/ /pubmed/34194299 http://dx.doi.org/10.3389/fnmol.2021.683035 Text en Copyright © 2021 Teo and Salinas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Neuroscience Teo, Samuel Salinas, Patricia C. Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation |
title | Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation |
title_full | Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation |
title_fullStr | Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation |
title_full_unstemmed | Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation |
title_short | Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation |
title_sort | wnt-frizzled signaling regulates activity-mediated synapse formation |
topic | Molecular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236581/ https://www.ncbi.nlm.nih.gov/pubmed/34194299 http://dx.doi.org/10.3389/fnmol.2021.683035 |
work_keys_str_mv | AT teosamuel wntfrizzledsignalingregulatesactivitymediatedsynapseformation AT salinaspatriciac wntfrizzledsignalingregulatesactivitymediatedsynapseformation |