A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy

Lipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biological processes, which could be a potential target site for photodynamic therapy (PDT) of cancer. Herein, a lipid droplet–targeted photosensitizer (BODSeI) is developed...

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Autores principales: Xia, Xiang, Wang, Ran, Hu, Yingqi, Liu, WeiJian, Liu, Ting, Sun, Wen, Fan, Jiangli, Peng, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236597/
https://www.ncbi.nlm.nih.gov/pubmed/34195177
http://dx.doi.org/10.3389/fchem.2021.701771
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author Xia, Xiang
Wang, Ran
Hu, Yingqi
Liu, WeiJian
Liu, Ting
Sun, Wen
Fan, Jiangli
Peng, Xiaojun
author_facet Xia, Xiang
Wang, Ran
Hu, Yingqi
Liu, WeiJian
Liu, Ting
Sun, Wen
Fan, Jiangli
Peng, Xiaojun
author_sort Xia, Xiang
collection PubMed
description Lipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biological processes, which could be a potential target site for photodynamic therapy (PDT) of cancer. Herein, a lipid droplet–targeted photosensitizer (BODSeI) is developed, allowing for fluorescence imaging–guided PDT. Owing to the location of lipid droplets, BODSeI demonstrates enhanced PDT efficiency with an extremely low IC50 value (around 125 nM). Besides, BODSeI shows good biocompatibility and high photostability. Therefore, BODSeI is promising for droplet-location PDT, which may trigger wide interest for exploring the pathway of lipid droplet–location PDT.
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spelling pubmed-82365972021-06-29 A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy Xia, Xiang Wang, Ran Hu, Yingqi Liu, WeiJian Liu, Ting Sun, Wen Fan, Jiangli Peng, Xiaojun Front Chem Chemistry Lipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biological processes, which could be a potential target site for photodynamic therapy (PDT) of cancer. Herein, a lipid droplet–targeted photosensitizer (BODSeI) is developed, allowing for fluorescence imaging–guided PDT. Owing to the location of lipid droplets, BODSeI demonstrates enhanced PDT efficiency with an extremely low IC50 value (around 125 nM). Besides, BODSeI shows good biocompatibility and high photostability. Therefore, BODSeI is promising for droplet-location PDT, which may trigger wide interest for exploring the pathway of lipid droplet–location PDT. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8236597/ /pubmed/34195177 http://dx.doi.org/10.3389/fchem.2021.701771 Text en Copyright © 2021 Xia, Wang, Hu, Liu, Liu, Sun, Fan and Peng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Xia, Xiang
Wang, Ran
Hu, Yingqi
Liu, WeiJian
Liu, Ting
Sun, Wen
Fan, Jiangli
Peng, Xiaojun
A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy
title A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy
title_full A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy
title_fullStr A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy
title_full_unstemmed A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy
title_short A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy
title_sort novel photosensitizer for lipid droplet–location photodynamic therapy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236597/
https://www.ncbi.nlm.nih.gov/pubmed/34195177
http://dx.doi.org/10.3389/fchem.2021.701771
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