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Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis
Biomaterials are playing an increased role in the regeneration of damaged or absent bone tissue in the context of trauma, non-union, infection or congenital abnormality. Restoration of not only the physical scaffold that bone provides, but also of its homeostatic functions as a calcium store and hem...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236622/ https://www.ncbi.nlm.nih.gov/pubmed/34195185 http://dx.doi.org/10.3389/fcell.2021.643781 |
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author | Crush, Jos Hussain, Ali Seah, K. T. M. Khan, Wasim S. |
author_facet | Crush, Jos Hussain, Ali Seah, K. T. M. Khan, Wasim S. |
author_sort | Crush, Jos |
collection | PubMed |
description | Biomaterials are playing an increased role in the regeneration of damaged or absent bone tissue in the context of trauma, non-union, infection or congenital abnormality. Restoration of not only the physical scaffold that bone provides, but also of its homeostatic functions as a calcium store and hematopoietic organ are the gold standards of any regenerative procedure. Bioactive glasses are of interest as they can bond with the host bone and induce further both bone and blood vessel growth. The composition of the bioactive glasses can be manipulated to maximize both osteogenesis and angiogenesis, producing a 3D scaffolds that induce bone growth whilst also providing a structure that resists physiological stresses. As the primary endpoints of studies looking at bioactive glasses are very often the ability to form substantial and healthy tissues, this review will focus on the methods used to study and quantify osteogenesis and angiogenesis in bioactive glass experiments. These methods are manifold, and their accuracy is of great importance in identifying plausible future bioactive glasses for clinical use. |
format | Online Article Text |
id | pubmed-8236622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82366222021-06-29 Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis Crush, Jos Hussain, Ali Seah, K. T. M. Khan, Wasim S. Front Cell Dev Biol Cell and Developmental Biology Biomaterials are playing an increased role in the regeneration of damaged or absent bone tissue in the context of trauma, non-union, infection or congenital abnormality. Restoration of not only the physical scaffold that bone provides, but also of its homeostatic functions as a calcium store and hematopoietic organ are the gold standards of any regenerative procedure. Bioactive glasses are of interest as they can bond with the host bone and induce further both bone and blood vessel growth. The composition of the bioactive glasses can be manipulated to maximize both osteogenesis and angiogenesis, producing a 3D scaffolds that induce bone growth whilst also providing a structure that resists physiological stresses. As the primary endpoints of studies looking at bioactive glasses are very often the ability to form substantial and healthy tissues, this review will focus on the methods used to study and quantify osteogenesis and angiogenesis in bioactive glass experiments. These methods are manifold, and their accuracy is of great importance in identifying plausible future bioactive glasses for clinical use. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8236622/ /pubmed/34195185 http://dx.doi.org/10.3389/fcell.2021.643781 Text en Copyright © 2021 Crush, Hussain, Seah and Khan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Crush, Jos Hussain, Ali Seah, K. T. M. Khan, Wasim S. Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis |
title | Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis |
title_full | Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis |
title_fullStr | Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis |
title_full_unstemmed | Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis |
title_short | Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis |
title_sort | bioactive glass: methods for assessing angiogenesis and osteogenesis |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236622/ https://www.ncbi.nlm.nih.gov/pubmed/34195185 http://dx.doi.org/10.3389/fcell.2021.643781 |
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