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Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance
Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in developed countries. Features such as dense stroma microenvironment, abnormal signaling pathways, and genetic heterogeneity of the tumors contribute to its chemoresistant characteri...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236623/ https://www.ncbi.nlm.nih.gov/pubmed/34195085 http://dx.doi.org/10.3389/fonc.2021.683788 |
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author | Xelwa, Ntombikayise Candy, Geoffrey Patrick Devar, John Omoshoro-Jones, Jones Smith, Martin Nweke, Ekene Emmanuel |
author_facet | Xelwa, Ntombikayise Candy, Geoffrey Patrick Devar, John Omoshoro-Jones, Jones Smith, Martin Nweke, Ekene Emmanuel |
author_sort | Xelwa, Ntombikayise |
collection | PubMed |
description | Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in developed countries. Features such as dense stroma microenvironment, abnormal signaling pathways, and genetic heterogeneity of the tumors contribute to its chemoresistant characteristics. Amongst these features, growth factors have been observed to play crucial roles in cancer cell survival, progression, and chemoresistance. Here we review the role of the individual growth factors in pancreatic cancer chemoresistance. Importantly, the interplay between the tumor microenvironment and chemoresistance is explored in the context of pivotal role played by growth factors. We further describe current and future potential therapeutic targeting of these factors. |
format | Online Article Text |
id | pubmed-8236623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82366232021-06-29 Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance Xelwa, Ntombikayise Candy, Geoffrey Patrick Devar, John Omoshoro-Jones, Jones Smith, Martin Nweke, Ekene Emmanuel Front Oncol Oncology Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in developed countries. Features such as dense stroma microenvironment, abnormal signaling pathways, and genetic heterogeneity of the tumors contribute to its chemoresistant characteristics. Amongst these features, growth factors have been observed to play crucial roles in cancer cell survival, progression, and chemoresistance. Here we review the role of the individual growth factors in pancreatic cancer chemoresistance. Importantly, the interplay between the tumor microenvironment and chemoresistance is explored in the context of pivotal role played by growth factors. We further describe current and future potential therapeutic targeting of these factors. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8236623/ /pubmed/34195085 http://dx.doi.org/10.3389/fonc.2021.683788 Text en Copyright © 2021 Xelwa, Candy, Devar, Omoshoro-Jones, Smith and Nweke https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Xelwa, Ntombikayise Candy, Geoffrey Patrick Devar, John Omoshoro-Jones, Jones Smith, Martin Nweke, Ekene Emmanuel Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
title | Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
title_full | Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
title_fullStr | Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
title_full_unstemmed | Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
title_short | Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance |
title_sort | targeting growth factor signaling pathways in pancreatic cancer: towards inhibiting chemoresistance |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236623/ https://www.ncbi.nlm.nih.gov/pubmed/34195085 http://dx.doi.org/10.3389/fonc.2021.683788 |
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