Impairment of Cyclo-oxygenase-2 Function Results in Abnormal Growth Plate Development and Bone Microarchitecture but Does Not Affect Longitudinal Growth of the Long Bones in Skeletally Immature Mice

OBJECTIVE: Despite the general awareness that cyclo-oxygenase-2 (COX-2) is crucial for endochondral ossification, the role of COX-2 in skeletal development is largely unknown. We hypothesized that inhibition or genetic loss of COX-2 leads to impaired growth plate development and consequently impaire...

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Detalles Bibliográficos
Autores principales: Caron, Marjolein M. J., Castermans, Tessy M. R., van Rietbergen, Bert, Haartmans, Mirella J. J., van Rhijn, Lodewijk W., Witlox, Adhiambo M. A., Welting, Tim J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236650/
https://www.ncbi.nlm.nih.gov/pubmed/30880429
http://dx.doi.org/10.1177/1947603519833149

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