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Outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection
Premature infants are at risk for developing symptomatic postnatal cytomegalovirus (CMV) disease, including sepsis-like syndrome. We performed a retrospective case–control study including infants born before 32 weeks of gestation and diagnosed with symptomatic postnatal CMV infection during the neon...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nagoya University
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236679/ https://www.ncbi.nlm.nih.gov/pubmed/34239179 http://dx.doi.org/10.18999/nagjms.83.2.311 |
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author | Takemoto, Koji Oshiro, Makoto Sato, Yoshiaki Yamamoto, Hikaru Ito, Masatoki Hayashi, Seiji Kato, Eiko Kato, Yuichi Hayakawa, Masahiro |
author_facet | Takemoto, Koji Oshiro, Makoto Sato, Yoshiaki Yamamoto, Hikaru Ito, Masatoki Hayashi, Seiji Kato, Eiko Kato, Yuichi Hayakawa, Masahiro |
author_sort | Takemoto, Koji |
collection | PubMed |
description | Premature infants are at risk for developing symptomatic postnatal cytomegalovirus (CMV) disease, including sepsis-like syndrome. We performed a retrospective case–control study including infants born before 32 weeks of gestation and diagnosed with symptomatic postnatal CMV infection during the neonatal period. Neurodevelopmental outcome was evaluated using the Kyoto Scale of Psychological Development 2001 at 18 months of corrected age and at 3 years of age. Twenty-four infants were diagnosed with postnatal CMV infection; of them, 14 had sepsis-like symptoms and 10 had laboratory test abnormalities only. Home oxygen therapy was used significantly higher in the CMV-positive group compared with the control group at hospital discharge (52% vs 21%, P=0.032). The incidence of neurodevelopmental impairment was not significantly different between the two groups at 18 months of corrected age (29% vs 17%, P=0.48) and at 3 years of age (43% vs 29%, P=0.34). Postnatal CMV infection did not have a significant influence on neurodevelopmental outcomes of symptomatic preterm infants, although those in the CMV-positive group appeared worse. Larger studies with long-term follow-up are needed for a better understanding of continued neurodevelopmental outcomes in preterm infants with postnatal CMV infection. |
format | Online Article Text |
id | pubmed-8236679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nagoya University |
record_format | MEDLINE/PubMed |
spelling | pubmed-82366792021-07-07 Outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection Takemoto, Koji Oshiro, Makoto Sato, Yoshiaki Yamamoto, Hikaru Ito, Masatoki Hayashi, Seiji Kato, Eiko Kato, Yuichi Hayakawa, Masahiro Nagoya J Med Sci Original Paper Premature infants are at risk for developing symptomatic postnatal cytomegalovirus (CMV) disease, including sepsis-like syndrome. We performed a retrospective case–control study including infants born before 32 weeks of gestation and diagnosed with symptomatic postnatal CMV infection during the neonatal period. Neurodevelopmental outcome was evaluated using the Kyoto Scale of Psychological Development 2001 at 18 months of corrected age and at 3 years of age. Twenty-four infants were diagnosed with postnatal CMV infection; of them, 14 had sepsis-like symptoms and 10 had laboratory test abnormalities only. Home oxygen therapy was used significantly higher in the CMV-positive group compared with the control group at hospital discharge (52% vs 21%, P=0.032). The incidence of neurodevelopmental impairment was not significantly different between the two groups at 18 months of corrected age (29% vs 17%, P=0.48) and at 3 years of age (43% vs 29%, P=0.34). Postnatal CMV infection did not have a significant influence on neurodevelopmental outcomes of symptomatic preterm infants, although those in the CMV-positive group appeared worse. Larger studies with long-term follow-up are needed for a better understanding of continued neurodevelopmental outcomes in preterm infants with postnatal CMV infection. Nagoya University 2021-05 /pmc/articles/PMC8236679/ /pubmed/34239179 http://dx.doi.org/10.18999/nagjms.83.2.311 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Original Paper Takemoto, Koji Oshiro, Makoto Sato, Yoshiaki Yamamoto, Hikaru Ito, Masatoki Hayashi, Seiji Kato, Eiko Kato, Yuichi Hayakawa, Masahiro Outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection |
title | Outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection |
title_full | Outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection |
title_fullStr | Outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection |
title_full_unstemmed | Outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection |
title_short | Outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection |
title_sort | outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236679/ https://www.ncbi.nlm.nih.gov/pubmed/34239179 http://dx.doi.org/10.18999/nagjms.83.2.311 |
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