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Tooth brushing, tooth loss, and risk of upper aerodigestive tract cancer: a cohort study of Japanese dentisits

Previous studies have focused on the association between poor oral health and upper aerodigestive tract (UADT) cancer. However, whether toothbrushing and tooth loss are associated with UADT cancer risk is still unclear. Therefore, we investigated the association between toothbrushing or tooth loss a...

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Autores principales: Tsukamoto, Mineko, Naito, Mariko, Wakai, Kenji, Naito, Toru, Kojima, Masaaki, Umemura, Osami, Yokota, Makoto, Hanada, Nobuhiro, Kawamura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236682/
https://www.ncbi.nlm.nih.gov/pubmed/34239181
http://dx.doi.org/10.18999/nagjms.83.2.331
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author Tsukamoto, Mineko
Naito, Mariko
Wakai, Kenji
Naito, Toru
Kojima, Masaaki
Umemura, Osami
Yokota, Makoto
Hanada, Nobuhiro
Kawamura, Takashi
author_facet Tsukamoto, Mineko
Naito, Mariko
Wakai, Kenji
Naito, Toru
Kojima, Masaaki
Umemura, Osami
Yokota, Makoto
Hanada, Nobuhiro
Kawamura, Takashi
author_sort Tsukamoto, Mineko
collection PubMed
description Previous studies have focused on the association between poor oral health and upper aerodigestive tract (UADT) cancer. However, whether toothbrushing and tooth loss are associated with UADT cancer risk is still unclear. Therefore, we investigated the association between toothbrushing or tooth loss and UADT cancer in the Longitudinal Evaluation of Multi-phasic, Odontological, and Nutritional Associations in Dentists (LEMONADE) cohort study. From 2001 to 2006, we recruited 20,445 dentists (mean age ± standard deviation, 51.8 ± 12.0 years; 1,607 women [7.9%]) and followed for incidence or mortality of UADT cancer through March 2014. Information on lifestyle and oral health was collected by the baseline questionnaire. The Cox proportional hazards model was used to estimate hazard ratios (HRs) for UADT cancer and corresponding 95% confidence intervals (CI) for brushing frequency and tooth loss with adjustment for covariates. During the mean follow-up of 9.5 years, we confirmed 62 incident or fatal cases of UADT cancer. Infrequent toothbrushing (< 2 times/day) was significantly associated with increased risk of UADT cancer (multivariate HR = 2.13, 95% CI: 1.04–4.37). On the contrary, tooth loss was not significantly correlated with UADT cancer risk; multivariate HR was 1.03 (95% CI: 0.41–2.61) for loss of 15–27 teeth and 1.37 (0.50–3.75) for that of 28 teeth compared to tooth loss of 0–14 teeth. In conclusion, Infrequent toothbrushing was significantly associated with the risk of UADT cancer.
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spelling pubmed-82366822021-07-07 Tooth brushing, tooth loss, and risk of upper aerodigestive tract cancer: a cohort study of Japanese dentisits Tsukamoto, Mineko Naito, Mariko Wakai, Kenji Naito, Toru Kojima, Masaaki Umemura, Osami Yokota, Makoto Hanada, Nobuhiro Kawamura, Takashi Nagoya J Med Sci Original Paper Previous studies have focused on the association between poor oral health and upper aerodigestive tract (UADT) cancer. However, whether toothbrushing and tooth loss are associated with UADT cancer risk is still unclear. Therefore, we investigated the association between toothbrushing or tooth loss and UADT cancer in the Longitudinal Evaluation of Multi-phasic, Odontological, and Nutritional Associations in Dentists (LEMONADE) cohort study. From 2001 to 2006, we recruited 20,445 dentists (mean age ± standard deviation, 51.8 ± 12.0 years; 1,607 women [7.9%]) and followed for incidence or mortality of UADT cancer through March 2014. Information on lifestyle and oral health was collected by the baseline questionnaire. The Cox proportional hazards model was used to estimate hazard ratios (HRs) for UADT cancer and corresponding 95% confidence intervals (CI) for brushing frequency and tooth loss with adjustment for covariates. During the mean follow-up of 9.5 years, we confirmed 62 incident or fatal cases of UADT cancer. Infrequent toothbrushing (< 2 times/day) was significantly associated with increased risk of UADT cancer (multivariate HR = 2.13, 95% CI: 1.04–4.37). On the contrary, tooth loss was not significantly correlated with UADT cancer risk; multivariate HR was 1.03 (95% CI: 0.41–2.61) for loss of 15–27 teeth and 1.37 (0.50–3.75) for that of 28 teeth compared to tooth loss of 0–14 teeth. In conclusion, Infrequent toothbrushing was significantly associated with the risk of UADT cancer. Nagoya University 2021-05 /pmc/articles/PMC8236682/ /pubmed/34239181 http://dx.doi.org/10.18999/nagjms.83.2.331 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Paper
Tsukamoto, Mineko
Naito, Mariko
Wakai, Kenji
Naito, Toru
Kojima, Masaaki
Umemura, Osami
Yokota, Makoto
Hanada, Nobuhiro
Kawamura, Takashi
Tooth brushing, tooth loss, and risk of upper aerodigestive tract cancer: a cohort study of Japanese dentisits
title Tooth brushing, tooth loss, and risk of upper aerodigestive tract cancer: a cohort study of Japanese dentisits
title_full Tooth brushing, tooth loss, and risk of upper aerodigestive tract cancer: a cohort study of Japanese dentisits
title_fullStr Tooth brushing, tooth loss, and risk of upper aerodigestive tract cancer: a cohort study of Japanese dentisits
title_full_unstemmed Tooth brushing, tooth loss, and risk of upper aerodigestive tract cancer: a cohort study of Japanese dentisits
title_short Tooth brushing, tooth loss, and risk of upper aerodigestive tract cancer: a cohort study of Japanese dentisits
title_sort tooth brushing, tooth loss, and risk of upper aerodigestive tract cancer: a cohort study of japanese dentisits
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236682/
https://www.ncbi.nlm.nih.gov/pubmed/34239181
http://dx.doi.org/10.18999/nagjms.83.2.331
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