Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis

This study investigated lipid metabolism in broilers with spontaneous femoral head necrosis (FHN) by determining the levels of markers of the blood biochemistry and bone metabolism. The birds were divided into a normal group and FHN group according to the femoral head scores of 3-, 4-, and 5-week-ol...

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Detalles Bibliográficos
Autores principales: Fan, Rubin, Liu, Kangping, Zhou, Zhenlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236708/
https://www.ncbi.nlm.nih.gov/pubmed/34194339
http://dx.doi.org/10.3389/fphys.2021.685968
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author Fan, Rubin
Liu, Kangping
Zhou, Zhenlei
author_facet Fan, Rubin
Liu, Kangping
Zhou, Zhenlei
author_sort Fan, Rubin
collection PubMed
description This study investigated lipid metabolism in broilers with spontaneous femoral head necrosis (FHN) by determining the levels of markers of the blood biochemistry and bone metabolism. The birds were divided into a normal group and FHN group according to the femoral head scores of 3-, 4-, and 5-week-old chickens with FHN, and a comparative study was conducted. The study showed that spontaneous FHN broilers had a lipid metabolism disorder, hyperlipidemia, and an accumulation of lipid droplets in the femur. In addition, there were significant changes in the bone parameters and blood bone biochemistry markers, and the expression of genes related to lipid metabolism in the femoral head was also significantly increased. Therefore, FHN may result from dyslipidemia, which affects the bone growth and development of broilers.
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spelling pubmed-82367082021-06-29 Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis Fan, Rubin Liu, Kangping Zhou, Zhenlei Front Physiol Physiology This study investigated lipid metabolism in broilers with spontaneous femoral head necrosis (FHN) by determining the levels of markers of the blood biochemistry and bone metabolism. The birds were divided into a normal group and FHN group according to the femoral head scores of 3-, 4-, and 5-week-old chickens with FHN, and a comparative study was conducted. The study showed that spontaneous FHN broilers had a lipid metabolism disorder, hyperlipidemia, and an accumulation of lipid droplets in the femur. In addition, there were significant changes in the bone parameters and blood bone biochemistry markers, and the expression of genes related to lipid metabolism in the femoral head was also significantly increased. Therefore, FHN may result from dyslipidemia, which affects the bone growth and development of broilers. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8236708/ /pubmed/34194339 http://dx.doi.org/10.3389/fphys.2021.685968 Text en Copyright © 2021 Fan, Liu and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Fan, Rubin
Liu, Kangping
Zhou, Zhenlei
Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis
title Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis
title_full Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis
title_fullStr Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis
title_full_unstemmed Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis
title_short Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis
title_sort abnormal lipid profile in fast-growing broilers with spontaneous femoral head necrosis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236708/
https://www.ncbi.nlm.nih.gov/pubmed/34194339
http://dx.doi.org/10.3389/fphys.2021.685968
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AT liukangping abnormallipidprofileinfastgrowingbroilerswithspontaneousfemoralheadnecrosis
AT zhouzhenlei abnormallipidprofileinfastgrowingbroilerswithspontaneousfemoralheadnecrosis

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