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Utilization of Magnesium for the Treatment of Chronic Pain

CONTEXT: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. EVIDENCE ACQUISITION: Nar...

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Detalles Bibliográficos
Autores principales: Urits, Ivan, Jung, Jai Won, Amgalan, Ariunzaya, Fortier, Luc, Anya, Anthony, Wesp, Brendan, Orhurhu, Vwaire, Cornett, Elyse M, Kaye, Alan D., Imani, Farnad, Varrassi, Giustino, Liu, Henry, Viswanath, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236839/
https://www.ncbi.nlm.nih.gov/pubmed/34221945
http://dx.doi.org/10.5812/aapm.112348
Descripción
Sumario:CONTEXT: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. EVIDENCE ACQUISITION: Narrative review. RESULTS: There are several treatment options, including pharmacological therapy, physical rehabilitation, psychological therapies, and surgical interventions, for chronic pain management. Magnesium has been FDA-approved for several indications including hypomagnesemia, arrhythmia, prevention of seizures in eclampsia/preeclampsia, and constipation. Magnesium has been used for numerous off-label uses, notably for acute and chronic pain management. The mechanism of magnesium in pain management is primarily through its action as a voltage-gated antagonist of NMDA receptors, which are involved in pain transduction. CONCLUSIONS: This narrative review will focus on the current evidence and data surrounding the utilization of magnesium as a treatment option for chronic pain.