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Utilization of Magnesium for the Treatment of Chronic Pain
CONTEXT: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. EVIDENCE ACQUISITION: Nar...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236839/ https://www.ncbi.nlm.nih.gov/pubmed/34221945 http://dx.doi.org/10.5812/aapm.112348 |
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author | Urits, Ivan Jung, Jai Won Amgalan, Ariunzaya Fortier, Luc Anya, Anthony Wesp, Brendan Orhurhu, Vwaire Cornett, Elyse M Kaye, Alan D. Imani, Farnad Varrassi, Giustino Liu, Henry Viswanath, Omar |
author_facet | Urits, Ivan Jung, Jai Won Amgalan, Ariunzaya Fortier, Luc Anya, Anthony Wesp, Brendan Orhurhu, Vwaire Cornett, Elyse M Kaye, Alan D. Imani, Farnad Varrassi, Giustino Liu, Henry Viswanath, Omar |
author_sort | Urits, Ivan |
collection | PubMed |
description | CONTEXT: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. EVIDENCE ACQUISITION: Narrative review. RESULTS: There are several treatment options, including pharmacological therapy, physical rehabilitation, psychological therapies, and surgical interventions, for chronic pain management. Magnesium has been FDA-approved for several indications including hypomagnesemia, arrhythmia, prevention of seizures in eclampsia/preeclampsia, and constipation. Magnesium has been used for numerous off-label uses, notably for acute and chronic pain management. The mechanism of magnesium in pain management is primarily through its action as a voltage-gated antagonist of NMDA receptors, which are involved in pain transduction. CONCLUSIONS: This narrative review will focus on the current evidence and data surrounding the utilization of magnesium as a treatment option for chronic pain. |
format | Online Article Text |
id | pubmed-8236839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-82368392021-07-02 Utilization of Magnesium for the Treatment of Chronic Pain Urits, Ivan Jung, Jai Won Amgalan, Ariunzaya Fortier, Luc Anya, Anthony Wesp, Brendan Orhurhu, Vwaire Cornett, Elyse M Kaye, Alan D. Imani, Farnad Varrassi, Giustino Liu, Henry Viswanath, Omar Anesth Pain Med Review Article CONTEXT: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. EVIDENCE ACQUISITION: Narrative review. RESULTS: There are several treatment options, including pharmacological therapy, physical rehabilitation, psychological therapies, and surgical interventions, for chronic pain management. Magnesium has been FDA-approved for several indications including hypomagnesemia, arrhythmia, prevention of seizures in eclampsia/preeclampsia, and constipation. Magnesium has been used for numerous off-label uses, notably for acute and chronic pain management. The mechanism of magnesium in pain management is primarily through its action as a voltage-gated antagonist of NMDA receptors, which are involved in pain transduction. CONCLUSIONS: This narrative review will focus on the current evidence and data surrounding the utilization of magnesium as a treatment option for chronic pain. Kowsar 2021-02-06 /pmc/articles/PMC8236839/ /pubmed/34221945 http://dx.doi.org/10.5812/aapm.112348 Text en Copyright © 2021, Author(s) https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Review Article Urits, Ivan Jung, Jai Won Amgalan, Ariunzaya Fortier, Luc Anya, Anthony Wesp, Brendan Orhurhu, Vwaire Cornett, Elyse M Kaye, Alan D. Imani, Farnad Varrassi, Giustino Liu, Henry Viswanath, Omar Utilization of Magnesium for the Treatment of Chronic Pain |
title | Utilization of Magnesium for the Treatment of Chronic Pain |
title_full | Utilization of Magnesium for the Treatment of Chronic Pain |
title_fullStr | Utilization of Magnesium for the Treatment of Chronic Pain |
title_full_unstemmed | Utilization of Magnesium for the Treatment of Chronic Pain |
title_short | Utilization of Magnesium for the Treatment of Chronic Pain |
title_sort | utilization of magnesium for the treatment of chronic pain |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236839/ https://www.ncbi.nlm.nih.gov/pubmed/34221945 http://dx.doi.org/10.5812/aapm.112348 |
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