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Utilization of Magnesium for the Treatment of Chronic Pain

CONTEXT: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. EVIDENCE ACQUISITION: Nar...

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Autores principales: Urits, Ivan, Jung, Jai Won, Amgalan, Ariunzaya, Fortier, Luc, Anya, Anthony, Wesp, Brendan, Orhurhu, Vwaire, Cornett, Elyse M, Kaye, Alan D., Imani, Farnad, Varrassi, Giustino, Liu, Henry, Viswanath, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236839/
https://www.ncbi.nlm.nih.gov/pubmed/34221945
http://dx.doi.org/10.5812/aapm.112348
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author Urits, Ivan
Jung, Jai Won
Amgalan, Ariunzaya
Fortier, Luc
Anya, Anthony
Wesp, Brendan
Orhurhu, Vwaire
Cornett, Elyse M
Kaye, Alan D.
Imani, Farnad
Varrassi, Giustino
Liu, Henry
Viswanath, Omar
author_facet Urits, Ivan
Jung, Jai Won
Amgalan, Ariunzaya
Fortier, Luc
Anya, Anthony
Wesp, Brendan
Orhurhu, Vwaire
Cornett, Elyse M
Kaye, Alan D.
Imani, Farnad
Varrassi, Giustino
Liu, Henry
Viswanath, Omar
author_sort Urits, Ivan
collection PubMed
description CONTEXT: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. EVIDENCE ACQUISITION: Narrative review. RESULTS: There are several treatment options, including pharmacological therapy, physical rehabilitation, psychological therapies, and surgical interventions, for chronic pain management. Magnesium has been FDA-approved for several indications including hypomagnesemia, arrhythmia, prevention of seizures in eclampsia/preeclampsia, and constipation. Magnesium has been used for numerous off-label uses, notably for acute and chronic pain management. The mechanism of magnesium in pain management is primarily through its action as a voltage-gated antagonist of NMDA receptors, which are involved in pain transduction. CONCLUSIONS: This narrative review will focus on the current evidence and data surrounding the utilization of magnesium as a treatment option for chronic pain.
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spelling pubmed-82368392021-07-02 Utilization of Magnesium for the Treatment of Chronic Pain Urits, Ivan Jung, Jai Won Amgalan, Ariunzaya Fortier, Luc Anya, Anthony Wesp, Brendan Orhurhu, Vwaire Cornett, Elyse M Kaye, Alan D. Imani, Farnad Varrassi, Giustino Liu, Henry Viswanath, Omar Anesth Pain Med Review Article CONTEXT: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. EVIDENCE ACQUISITION: Narrative review. RESULTS: There are several treatment options, including pharmacological therapy, physical rehabilitation, psychological therapies, and surgical interventions, for chronic pain management. Magnesium has been FDA-approved for several indications including hypomagnesemia, arrhythmia, prevention of seizures in eclampsia/preeclampsia, and constipation. Magnesium has been used for numerous off-label uses, notably for acute and chronic pain management. The mechanism of magnesium in pain management is primarily through its action as a voltage-gated antagonist of NMDA receptors, which are involved in pain transduction. CONCLUSIONS: This narrative review will focus on the current evidence and data surrounding the utilization of magnesium as a treatment option for chronic pain. Kowsar 2021-02-06 /pmc/articles/PMC8236839/ /pubmed/34221945 http://dx.doi.org/10.5812/aapm.112348 Text en Copyright © 2021, Author(s) https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Review Article
Urits, Ivan
Jung, Jai Won
Amgalan, Ariunzaya
Fortier, Luc
Anya, Anthony
Wesp, Brendan
Orhurhu, Vwaire
Cornett, Elyse M
Kaye, Alan D.
Imani, Farnad
Varrassi, Giustino
Liu, Henry
Viswanath, Omar
Utilization of Magnesium for the Treatment of Chronic Pain
title Utilization of Magnesium for the Treatment of Chronic Pain
title_full Utilization of Magnesium for the Treatment of Chronic Pain
title_fullStr Utilization of Magnesium for the Treatment of Chronic Pain
title_full_unstemmed Utilization of Magnesium for the Treatment of Chronic Pain
title_short Utilization of Magnesium for the Treatment of Chronic Pain
title_sort utilization of magnesium for the treatment of chronic pain
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236839/
https://www.ncbi.nlm.nih.gov/pubmed/34221945
http://dx.doi.org/10.5812/aapm.112348
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