Genetic Analysis of Tryptophan Metabolism Genes in Sporadic Amyotrophic Lateral Sclerosis

The essential amino acid tryptophan (TRP) is the initiating metabolite of the kynurenine pathway (KP), which can be upregulated by inflammatory conditions in cells. Neuroinflammation-triggered activation of the KP and excessive production of the KP metabolite quinolinic acid are common features of m...

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Detalles Bibliográficos
Autores principales: Fifita, Jennifer A., Chan Moi Fat, Sandrine, McCann, Emily P., Williams, Kelly L., Twine, Natalie A., Bauer, Denis C., Rowe, Dominic B., Pamphlett, Roger, Kiernan, Matthew C., Tan, Vanessa X., Blair, Ian P., Guillemin, Gilles J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236844/
https://www.ncbi.nlm.nih.gov/pubmed/34194442
http://dx.doi.org/10.3389/fimmu.2021.701550

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