The RNA-Binding Proteins SRP14 and HMGB3 Control HIV-1 Tat mRNA Processing and Translation During HIV-1 Latency

HIV-1 Tat protein is essential for virus production. RNA-binding proteins that facilitate Tat production may be absent or downregulated in resting CD4(+) T-cells, the main reservoir of latent HIV in people with HIV (PWH) on antiretroviral therapy (ART). In this study, we examined the role of Tat RNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Khoury, Georges, Lee, Michelle Y., Ramarathinam, Sri H., McMahon, James, Purcell, Anthony W., Sonza, Secondo, Lewin, Sharon R., Purcell, Damian F. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236859/
https://www.ncbi.nlm.nih.gov/pubmed/34194479
http://dx.doi.org/10.3389/fgene.2021.680725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236859/
https://www.ncbi.nlm.nih.gov/pubmed/34194479
http://dx.doi.org/10.3389/fgene.2021.680725

Ejemplares similares