Cargando…
The Biological Function Delineated Across Pan-Cancer Levels Through lncRNA-Based Prognostic Risk Assessment Factors for Pancreatic Cancer
Long non-coding RNAs (lncRNAs) play key roles in tumors and function not only as important molecular markers for cancer prognosis, but also as molecular characteristics at the pan-cancer level. Because of the poor prognosis of pancreatic cancer, accurate assessment of prognosis is a key issue in the...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236889/ https://www.ncbi.nlm.nih.gov/pubmed/34195204 http://dx.doi.org/10.3389/fcell.2021.694652 |
_version_ | 1783714639271428096 |
---|---|
author | Tang, Xudong Zhang, Mengyan Sun, Liang Xu, Fengyan Peng, Xin Zhang, Yan Deng, Ying Wu, Shuliang |
author_facet | Tang, Xudong Zhang, Mengyan Sun, Liang Xu, Fengyan Peng, Xin Zhang, Yan Deng, Ying Wu, Shuliang |
author_sort | Tang, Xudong |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) play key roles in tumors and function not only as important molecular markers for cancer prognosis, but also as molecular characteristics at the pan-cancer level. Because of the poor prognosis of pancreatic cancer, accurate assessment of prognosis is a key issue in the development of treatment plans for pancreatic cancer. Here we analyzed pancreatic cancer data from The Cancer Genome Atlas and The Genotype Tissue Expression database using Cox regression and lasso regression in analyses using a combination of the two databases as well as only The Cancer Genome Atlas database (Cancer Genome Atlas Research Network et al., 2013). A prognostic risk score model with significant correlation with pancreatic cancer survival was constructed, and two lncRNAs were investigated. Additional analysis of 33 cancers using the two lncRNAs showed that lncRNA TsPOAP1-AS1 was a prognostic marker of seven cancers, among which pancreatic cancer was the most significant, and lncRNA mi600hg was a prognostic marker of ovarian cancer and pancreatic cancer. LncRNA TsPOAP1-AS1 is associated with clinical stage and tumor mutation burden of some cancers as well as a strong degree of immune infiltration in many cancers, while a strong correlation between lncRNA mi600hg and microsatellite instability was observed in several cancers. The results of this study help further our understanding of the different functions of lncRNAs in cancer and may aid in the clinical application of lncRNAs as prognostic factors for cancer. |
format | Online Article Text |
id | pubmed-8236889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82368892021-06-29 The Biological Function Delineated Across Pan-Cancer Levels Through lncRNA-Based Prognostic Risk Assessment Factors for Pancreatic Cancer Tang, Xudong Zhang, Mengyan Sun, Liang Xu, Fengyan Peng, Xin Zhang, Yan Deng, Ying Wu, Shuliang Front Cell Dev Biol Cell and Developmental Biology Long non-coding RNAs (lncRNAs) play key roles in tumors and function not only as important molecular markers for cancer prognosis, but also as molecular characteristics at the pan-cancer level. Because of the poor prognosis of pancreatic cancer, accurate assessment of prognosis is a key issue in the development of treatment plans for pancreatic cancer. Here we analyzed pancreatic cancer data from The Cancer Genome Atlas and The Genotype Tissue Expression database using Cox regression and lasso regression in analyses using a combination of the two databases as well as only The Cancer Genome Atlas database (Cancer Genome Atlas Research Network et al., 2013). A prognostic risk score model with significant correlation with pancreatic cancer survival was constructed, and two lncRNAs were investigated. Additional analysis of 33 cancers using the two lncRNAs showed that lncRNA TsPOAP1-AS1 was a prognostic marker of seven cancers, among which pancreatic cancer was the most significant, and lncRNA mi600hg was a prognostic marker of ovarian cancer and pancreatic cancer. LncRNA TsPOAP1-AS1 is associated with clinical stage and tumor mutation burden of some cancers as well as a strong degree of immune infiltration in many cancers, while a strong correlation between lncRNA mi600hg and microsatellite instability was observed in several cancers. The results of this study help further our understanding of the different functions of lncRNAs in cancer and may aid in the clinical application of lncRNAs as prognostic factors for cancer. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8236889/ /pubmed/34195204 http://dx.doi.org/10.3389/fcell.2021.694652 Text en Copyright © 2021 Tang, Zhang, Sun, Xu, Peng, Zhang, Deng and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Tang, Xudong Zhang, Mengyan Sun, Liang Xu, Fengyan Peng, Xin Zhang, Yan Deng, Ying Wu, Shuliang The Biological Function Delineated Across Pan-Cancer Levels Through lncRNA-Based Prognostic Risk Assessment Factors for Pancreatic Cancer |
title | The Biological Function Delineated Across Pan-Cancer Levels Through lncRNA-Based Prognostic Risk Assessment Factors for Pancreatic Cancer |
title_full | The Biological Function Delineated Across Pan-Cancer Levels Through lncRNA-Based Prognostic Risk Assessment Factors for Pancreatic Cancer |
title_fullStr | The Biological Function Delineated Across Pan-Cancer Levels Through lncRNA-Based Prognostic Risk Assessment Factors for Pancreatic Cancer |
title_full_unstemmed | The Biological Function Delineated Across Pan-Cancer Levels Through lncRNA-Based Prognostic Risk Assessment Factors for Pancreatic Cancer |
title_short | The Biological Function Delineated Across Pan-Cancer Levels Through lncRNA-Based Prognostic Risk Assessment Factors for Pancreatic Cancer |
title_sort | biological function delineated across pan-cancer levels through lncrna-based prognostic risk assessment factors for pancreatic cancer |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236889/ https://www.ncbi.nlm.nih.gov/pubmed/34195204 http://dx.doi.org/10.3389/fcell.2021.694652 |
work_keys_str_mv | AT tangxudong thebiologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT zhangmengyan thebiologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT sunliang thebiologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT xufengyan thebiologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT pengxin thebiologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT zhangyan thebiologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT dengying thebiologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT wushuliang thebiologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT tangxudong biologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT zhangmengyan biologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT sunliang biologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT xufengyan biologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT pengxin biologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT zhangyan biologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT dengying biologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer AT wushuliang biologicalfunctiondelineatedacrosspancancerlevelsthroughlncrnabasedprognosticriskassessmentfactorsforpancreaticcancer |