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Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation
Visual neuroadaptation is believed to play an important role in determining the final visual outcomes following intraocular lens (IOL) implantation. To investigate visual neuroadaptation in patients with age-related cataracts (ARCs) after phacoemulsification with multifocal and monofocal IOL implant...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236945/ https://www.ncbi.nlm.nih.gov/pubmed/34194292 http://dx.doi.org/10.3389/fnins.2021.648863 |
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author | Zhang, Li Lin, Duoru Wang, Yong Chen, Wan Xiao, Wei Xiang, Yi Zhu, Yi Chen, Chuan Dong, Xiying Liu, Yizhi Chen, Weirong Lin, Haotian |
author_facet | Zhang, Li Lin, Duoru Wang, Yong Chen, Wan Xiao, Wei Xiang, Yi Zhu, Yi Chen, Chuan Dong, Xiying Liu, Yizhi Chen, Weirong Lin, Haotian |
author_sort | Zhang, Li |
collection | PubMed |
description | Visual neuroadaptation is believed to play an important role in determining the final visual outcomes following intraocular lens (IOL) implantation. To investigate visual neuroadaptation in patients with age-related cataracts (ARCs) after phacoemulsification with multifocal and monofocal IOL implantation, we conducted a prospective, controlled clinical trial in Zhongshan Ophthalmology Center. This study included 22 patients with bilateral ARCs: 11 patients underwent phacoemulsification and multifocal IOL (Mu-IOL) implantation, and 11 patients underwent phacoemulsification and monofocal IOL (Mo-IOL) implantation. Visual disturbances (glare and halos), visual function (including visual acuity, retinal straylight, contrast sensitivity, and visual evoked potentials) and visual cortical function (fractional amplitude of low-frequency fluctuations, fALFF) in Bowman’s areas 17–19 as the region of interest were assessed before and after surgeries. The results showed that the fALFF values of the visual cortex in the Mu-IOL group decreased at 1 week postoperatively and recovered to baseline at 3 months and then improved at 6 months, compared with preoperative levels (at a whole-brain threshold of P < 0.05, AlphaSim-corrected, voxels > 228, repeated measures analysis of variance). Significantly increased fALFF values in the visual cortex were detected 1 week after surgery in the Mo-IOL group and decreased to baseline at 3 and 6 months. The fALFF of the lingual gyrus was negatively correlated with visual disturbances (P < 0.05). To conclude, early postoperative visual neuroadaptation was detected in the Mu-IOL group by resting-state fMRI analysis. The different changing trends of postoperative fALFF values in the two groups indicated distinct neuroadaptations patterns after Mu-IOL and Mo-IOL implantation. |
format | Online Article Text |
id | pubmed-8236945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82369452021-06-29 Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation Zhang, Li Lin, Duoru Wang, Yong Chen, Wan Xiao, Wei Xiang, Yi Zhu, Yi Chen, Chuan Dong, Xiying Liu, Yizhi Chen, Weirong Lin, Haotian Front Neurosci Neuroscience Visual neuroadaptation is believed to play an important role in determining the final visual outcomes following intraocular lens (IOL) implantation. To investigate visual neuroadaptation in patients with age-related cataracts (ARCs) after phacoemulsification with multifocal and monofocal IOL implantation, we conducted a prospective, controlled clinical trial in Zhongshan Ophthalmology Center. This study included 22 patients with bilateral ARCs: 11 patients underwent phacoemulsification and multifocal IOL (Mu-IOL) implantation, and 11 patients underwent phacoemulsification and monofocal IOL (Mo-IOL) implantation. Visual disturbances (glare and halos), visual function (including visual acuity, retinal straylight, contrast sensitivity, and visual evoked potentials) and visual cortical function (fractional amplitude of low-frequency fluctuations, fALFF) in Bowman’s areas 17–19 as the region of interest were assessed before and after surgeries. The results showed that the fALFF values of the visual cortex in the Mu-IOL group decreased at 1 week postoperatively and recovered to baseline at 3 months and then improved at 6 months, compared with preoperative levels (at a whole-brain threshold of P < 0.05, AlphaSim-corrected, voxels > 228, repeated measures analysis of variance). Significantly increased fALFF values in the visual cortex were detected 1 week after surgery in the Mo-IOL group and decreased to baseline at 3 and 6 months. The fALFF of the lingual gyrus was negatively correlated with visual disturbances (P < 0.05). To conclude, early postoperative visual neuroadaptation was detected in the Mu-IOL group by resting-state fMRI analysis. The different changing trends of postoperative fALFF values in the two groups indicated distinct neuroadaptations patterns after Mu-IOL and Mo-IOL implantation. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8236945/ /pubmed/34194292 http://dx.doi.org/10.3389/fnins.2021.648863 Text en Copyright © 2021 Zhang, Lin, Wang, Chen, Xiao, Xiang, Zhu, Chen, Dong, Liu, Chen and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Li Lin, Duoru Wang, Yong Chen, Wan Xiao, Wei Xiang, Yi Zhu, Yi Chen, Chuan Dong, Xiying Liu, Yizhi Chen, Weirong Lin, Haotian Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
title | Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
title_full | Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
title_fullStr | Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
title_full_unstemmed | Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
title_short | Comparison of Visual Neuroadaptations After Multifocal and Monofocal Intraocular Lens Implantation |
title_sort | comparison of visual neuroadaptations after multifocal and monofocal intraocular lens implantation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236945/ https://www.ncbi.nlm.nih.gov/pubmed/34194292 http://dx.doi.org/10.3389/fnins.2021.648863 |
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