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Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome
BACKGROUNDS: Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes. However, the impact of GFR estimation methods on the accuracy and effectiveness of surr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Nephrology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237122/ https://www.ncbi.nlm.nih.gov/pubmed/34162048 http://dx.doi.org/10.23876/j.krcp.20.210 |
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author | Kim, Kipyo Baek, Eunji Go, Suryeong Son, Hyung-Eun Ryu, Ji-Young Yi, Yongjin Jeong, Jong Cheol Kim, Sejoong Chin, Ho Jun |
author_facet | Kim, Kipyo Baek, Eunji Go, Suryeong Son, Hyung-Eun Ryu, Ji-Young Yi, Yongjin Jeong, Jong Cheol Kim, Sejoong Chin, Ho Jun |
author_sort | Kim, Kipyo |
collection | PubMed |
description | BACKGROUNDS: Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes. However, the impact of GFR estimation methods on the accuracy and effectiveness of surrogate markers is unknown. METHODS: We retrospectively enrolled participants in health screening programs at three hospitals from 1995 to 2009. We defined two different participant groups as YR1 and YR3, which had available 1-year or 3-year eGFR values along with their baseline eGFR levels. We compared the effectiveness of eGFR percentage change or slope to estimate end-stage renal disease (ESRD) risk according to two estimating equations (modified Modification of Diet in Renal Disease equation [eGFRm] and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation [eGFRc]) for GFR. RESULTS: In the YR1 and YR3 groups, 9,971 and 10,171 candidates were enrolled and ESRD incidence during follow-up was 0.26% and 0.19%, respectively. The eGFR percentage change was more effective than eGFR slope in estimating ESRD risk, regardless of the method of estimation. A 40% of decline in eGFR was better than 30%, and a 3-year baseline period was better than a 1-year period for prediction accuracy. Although some diagnostic indices from the CKD-EPI equation were better, we found no significant differences in the discriminative ability and hazard ratios for incident ESRD between eGFRc and eGFRm in either eGFR percentage change or eGFR slope. CONCLUSION: There were no significant differences in the prediction accuracy of GFR percentage change or eGFR slope between eGFRc and eGFRm in the general population. |
format | Online Article Text |
id | pubmed-8237122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Korean Society of Nephrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-82371222021-07-07 Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome Kim, Kipyo Baek, Eunji Go, Suryeong Son, Hyung-Eun Ryu, Ji-Young Yi, Yongjin Jeong, Jong Cheol Kim, Sejoong Chin, Ho Jun Kidney Res Clin Pract Original Article BACKGROUNDS: Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes. However, the impact of GFR estimation methods on the accuracy and effectiveness of surrogate markers is unknown. METHODS: We retrospectively enrolled participants in health screening programs at three hospitals from 1995 to 2009. We defined two different participant groups as YR1 and YR3, which had available 1-year or 3-year eGFR values along with their baseline eGFR levels. We compared the effectiveness of eGFR percentage change or slope to estimate end-stage renal disease (ESRD) risk according to two estimating equations (modified Modification of Diet in Renal Disease equation [eGFRm] and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation [eGFRc]) for GFR. RESULTS: In the YR1 and YR3 groups, 9,971 and 10,171 candidates were enrolled and ESRD incidence during follow-up was 0.26% and 0.19%, respectively. The eGFR percentage change was more effective than eGFR slope in estimating ESRD risk, regardless of the method of estimation. A 40% of decline in eGFR was better than 30%, and a 3-year baseline period was better than a 1-year period for prediction accuracy. Although some diagnostic indices from the CKD-EPI equation were better, we found no significant differences in the discriminative ability and hazard ratios for incident ESRD between eGFRc and eGFRm in either eGFR percentage change or eGFR slope. CONCLUSION: There were no significant differences in the prediction accuracy of GFR percentage change or eGFR slope between eGFRc and eGFRm in the general population. The Korean Society of Nephrology 2021-06 2021-05-13 /pmc/articles/PMC8237122/ /pubmed/34162048 http://dx.doi.org/10.23876/j.krcp.20.210 Text en Copyright © 2021 The Korean Society of Nephrology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial and No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) which permits unrestricted non-commercial use, distribution of the material without any modifications, and reproduction in any medium, provided the original works properly cited. |
spellingShingle | Original Article Kim, Kipyo Baek, Eunji Go, Suryeong Son, Hyung-Eun Ryu, Ji-Young Yi, Yongjin Jeong, Jong Cheol Kim, Sejoong Chin, Ho Jun Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
title | Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
title_full | Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
title_fullStr | Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
title_full_unstemmed | Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
title_short | Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
title_sort | effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237122/ https://www.ncbi.nlm.nih.gov/pubmed/34162048 http://dx.doi.org/10.23876/j.krcp.20.210 |
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